Phenotypes associated with this allele

• Allele Symbol: Slc27a1^tm1Jkk
• Allele Name: targeted mutation 1, Jason Kim
• Allele ID: MGI:3038701
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc27a1^tm1Jkk/Slc27a1^tm1Jkk	involves: 129S/SvEv * C57BL/6J	MGI:3038847

Genotype
MGI:3038847

hm1

• Allelic Composition: Slc27a1^tm1Jkk/Slc27a1^tm1Jkk
• Genetic Background: involves: 129S/SvEv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal glucose homeostasis ( J:88657 )

• lipid infusion or high-fat diet did not reduce insulin-stimulated whole-body glucose turnover rate in mutants unlike in wild-type mice

• lipid infusion or high-fat diet did not alter whole body glucose metabolism in mutants unlike in wild-type mice

• insulin stimulated glucose uptake in brown adipose tissue was not significantly different between mutant and wild-type mice

abnormal lipid level ( J:88657 )

abnormal fatty acids level ( J:88657 )

• intramuscular fatty acid derived metabolite concentrations did not increase in mutants on a high-fat diet unlike in wild-type mice

abnormal skeletal muscle triglyceride level ( J:88657 )

• intramuscular triglyceride concentrations did not increase in mutants on a high-fat diet unlike in wild-type mice

muscle

abnormal skeletal muscle cell glucose uptake ( J:88657 )

• lipid infusion or high-fat diet did not reduce insulin-stimulated glucose uptake in skeletal muscle unlike in wild-type mice which did develop fat induced insulin resistance

abnormal skeletal muscle triglyceride level ( J:88657 )

• intramuscular triglyceride concentrations did not increase in mutants on a high-fat diet unlike in wild-type mice

cellular

abnormal skeletal muscle cell glucose uptake ( J:88657 )

• lipid infusion or high-fat diet did not reduce insulin-stimulated glucose uptake in skeletal muscle unlike in wild-type mice which did develop fat induced insulin resistance