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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd79atm3Cgn
targeted mutation 3, University of Cologne
MGI:3038712
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Cd79atm3Cgn/Cd79atm4.1Cgn involves: C57BL/6 * CBA MGI:3716169
cn2
 		Cd79atm3Cgn/Cd79atm3Cgn
Tg(Mx1-cre)1Cgn/? 		involves: C57BL/6 * CBA MGI:3716167


Genotype
MGI:3716169
ht1
Allelic
Composition		 Cd79atm3Cgn/Cd79atm4.1Cgn
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm3Cgn mutation (0 available); any Cd79a mutation (24 available)
Cd79atm4.1Cgn mutation (1 available); any Cd79a mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:88620 )
N
• following treatment with poly(I)/poly(C), B cell numbers are normal




Genotype
MGI:3716167
cn2
Allelic
Composition		 Cd79atm3Cgn/Cd79atm3Cgn
Tg(Mx1-cre)1Cgn/?
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm3Cgn mutation (0 available); any Cd79a mutation (24 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B cell number ( J:88620 )
• following treatment with poly(I)/poly(C), B cell numbers are decreased by up to 70% of wild-type numbers in the red pulp of the spleen
abnormal metallophilic macrophage morphology ( J:88620 )
• following treatment with poly(I)/poly(C), marginal metallophilic macrophages are decreased in number in areas where B cell numbers are reduced
abnormal spleen marginal zone macrophage morphology ( J:88620 )
• following treatment with poly(I)/poly(C), marginal zone metallophilic macrophages are decreased in number in areas where B cell numbers are reduced
abnormal spleen red pulp morphology ( J:88620 )
• following treatment with poly(I)/poly(C), B cell numbers are decreased by up to 70% of wild-type numbers in the red pulp of the spleen
• following treatment with poly(I)/poly(C), follicles are reduced in size

immune system
decreased B cell number ( J:88620 )
• following treatment with poly(I)/poly(C), B cell numbers are decreased by up to 70% of wild-type numbers in the red pulp of the spleen
abnormal metallophilic macrophage morphology ( J:88620 )
• following treatment with poly(I)/poly(C), marginal metallophilic macrophages are decreased in number in areas where B cell numbers are reduced
abnormal spleen marginal zone macrophage morphology ( J:88620 )
• following treatment with poly(I)/poly(C), marginal zone metallophilic macrophages are decreased in number in areas where B cell numbers are reduced
abnormal spleen red pulp morphology ( J:88620 )
• following treatment with poly(I)/poly(C), B cell numbers are decreased by up to 70% of wild-type numbers in the red pulp of the spleen
• following treatment with poly(I)/poly(C), follicles are reduced in size




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory