Phenotypes associated with this allele

• Allele Symbol: Fbxw7^tm1Sje
• Allele Name: targeted mutation 1, Stephen Elledge
• Allele ID: MGI:3038749
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fbxw7^tm1Sje/Fbxw7^tm1Sje	involves: 129S7/SvEvBrd * C57BL/6	MGI:3038804
ht2	Fbxw7^tm1Sje/Fbxw7^+	involves: 129S7/SvEvBrd * C57BL/6	MGI:3038805

Genotype
MGI:3038804

hm1

• Allelic Composition: Fbxw7^tm1Sje/Fbxw7^tm1Sje
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:88903 )

• embryos die around E10.5

cardiovascular system

abnormal blood vessel morphology ( J:88903 )

• reduced vasculature in the embryos and in the yolk sac

• most evident in the capillary beds underlying the neural tube

disorganized yolk sac vascular plexus ( J:88903 )

abnormal heart development ( J:88903 )

• normal looping morphogenesis followed by impaired chamber formation

• embryos do not form differentiated ventricles or atria but rather possess thickened looped tubes

• the abnormal hearts maintained contractility at E10.5

embryo

disorganized yolk sac vascular plexus ( J:88903 )

embryonic growth retardation ( J:88903 )

• at E9.5, gross underdevelopment of fore-, mid-, and hindbrain regions as well as incomplete neural tube closure

• mice do complete axial rotation and initiate branchial arch and anterior limb bud development successfully

decreased embryo size ( J:88903 )

• approximately 60% the size of normal littermates

open neural tube ( J:88903 )

• observed at E9.5 in many embryos

pale yolk sac ( J:88903 )

growth/size/body

embryonic growth retardation ( J:88903 )

• at E9.5, gross underdevelopment of fore-, mid-, and hindbrain regions as well as incomplete neural tube closure

• mice do complete axial rotation and initiate branchial arch and anterior limb bud development successfully

decreased embryo size ( J:88903 )

• approximately 60% the size of normal littermates

hematopoietic system

abnormal erythrocyte cell number ( J:88903 )

nervous system

open neural tube ( J:88903 )

• observed at E9.5 in many embryos

abnormal brain development ( J:88903 )

• gross underdevelopment of fore-, mid-, and hindbrain regions at E9.5

Genotype
MGI:3038805

ht2

• Allelic Composition: Fbxw7^tm1Sje/Fbxw7⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

neoplasm

neoplasm ( J:88903 )

N • mice did not develop spontaneous tumors for up to 1 year of age