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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cfbtm1Pkna
targeted mutation 1, Marcela Pekna
MGI:3038803
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cfbtm1Pkna/Cfbtm1Pkna D1.129P2-Cfbtm1Pkna MGI:3040864


Genotype
MGI:3040864
hm1
Allelic
Composition		 Cfbtm1Pkna/Cfbtm1Pkna
Genetic
Background		 D1.129P2-Cfbtm1Pkna
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cfbtm1Pkna mutation (0 available); any Cfb mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to induced arthritis ( J:88872 )
• arthritis develops in 100% of induced mice, however with reduced severity relative to control mice
• onset of induced arthritis is delayed relative to control mice but incidence is similar to that seen in wild-type mice

skeleton
decreased susceptibility to induced arthritis ( J:88872 )
• arthritis develops in 100% of induced mice, however with reduced severity relative to control mice
• onset of induced arthritis is delayed relative to control mice but incidence is similar to that seen in wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory