Phenotypes associated with this allele

• Allele Symbol: Ms4a1^tm1Tft
• Allele Name: targeted mutation 1, Thomas F Tedder
• Allele ID: MGI:3038963
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ms4a1^tm1Tft/Ms4a1^tm1Tft	involves: 129 * C57BL/6	MGI:3040502

Genotype
MGI:3040502

hm1

• Allelic Composition: Ms4a1^tm1Tft/Ms4a1^tm1Tft
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal B cell calcium ion homeostasis ( J:88933 )

• B-cells exhibit impaired IgM- and CD19-induced intracellular calcium responses

immune system

immune system phenotype ( J:88933 )

N • B cell development is largely normal, as was tissue localization, signal transduction, proliferation, and T cell-dependent antibody responses and affinity maturation

N • susceptibility to infection is not altered

abnormal B cell number ( J:88933 )

• about 50% reduction in numbers of IgM^hiB220^lo B cells in the spleen

increased transitional stage B cell number ( J:88933 )

• frequency and number of T1 cells is usually higher

decreased B-1 B cell number ( J:88933 )

• decrease in numbers of B1 cells within the peritoneal cavity

abnormal B cell physiology ( J:88933 )

• immature and mature B cell IgM expression is reduced by approximately 20-30% relative to those of wild-type controls

abnormal B cell calcium ion homeostasis ( J:88933 )

• B-cells exhibit impaired IgM- and CD19-induced intracellular calcium responses

hematopoietic system

abnormal B cell number ( J:88933 )

• about 50% reduction in numbers of IgM^hiB220^lo B cells in the spleen

increased transitional stage B cell number ( J:88933 )

• frequency and number of T1 cells is usually higher

decreased B-1 B cell number ( J:88933 )

• decrease in numbers of B1 cells within the peritoneal cavity

abnormal B cell physiology ( J:88933 )

• immature and mature B cell IgM expression is reduced by approximately 20-30% relative to those of wild-type controls

abnormal B cell calcium ion homeostasis ( J:88933 )

• B-cells exhibit impaired IgM- and CD19-induced intracellular calcium responses