All Phenotypes Calcr<tm1Dgal> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Calcr^tm1Dgal
targeted mutation 1, D L Galson
MGI:3038975

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Calcr^tm1Dgal/Calcr^tm1Dgal	Not Specified	MGI:3040610
ht2	Calcr^tm1Dgal/Calcr⁺	Not Specified	MGI:3040611
cx3	Calcr^tm1Dgal/Calcr⁺ Iapp^tm1Sgm/Iapp⁺	involves: 129P2/OlaHsd	MGI:3040612

Allelic Composition	Calcr^tm1Dgal/Calcr^tm1Dgal
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Calcr^tm1Dgal mutation (0 available); any Calcr mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:92983 )

• homozygous embryos start dying between E9.5 and E10.5

• no homozygous embryos are found after E10.5

Allelic Composition	Calcr^tm1Dgal/Calcr⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Calcr^tm1Dgal mutation (0 available); any Calcr mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

increased bone mineral density ( J:88964 )

• due to increased bone formation

increased bone mass ( J:88964 )

increased bone ossification ( J:88964 )

• increase in bone formation rate

• however, bone resorption is normal

Allelic Composition	Calcr^tm1Dgal/Calcr⁺ Iapp^tm1Sgm/Iapp⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Calcr^tm1Dgal mutation (0 available); any Calcr mutation (59 available)
Iapp^tm1Sgm mutation (2 available); any Iapp mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

increased osteoclast cell number ( J:88964 )

increased bone mass ( J:88964 )

increased bone ossification ( J:88964 )

• increase in bone formation rate

hematopoietic system

increased osteoclast cell number ( J:88964 )

immune system

increased osteoclast cell number ( J:88964 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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