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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ccna1tm1Coll
targeted mutation 1, William H Colledge
MGI:3038977
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ccna1tm1Coll/Ccna1tm1Coll involves: 129S/SvEv * MF1 MGI:3039386
ht2
 		Ccna1tm1Coll/Ccna1+ either: 129S/SvEv or (involves: 129S/SvEv * MF1) MGI:3039387


Genotype
MGI:3039386
hm1
Allelic
Composition		 Ccna1tm1Coll/Ccna1tm1Coll
Genetic
Background		 involves: 129S/SvEv * MF1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccna1tm1Coll mutation (0 available); any Ccna1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular

reproductive system
decreased testis weight ( J:89030 )
• combined testes weight in homozygotes is around half that in wild-type mice even though total body weights are not significantly different
arrest of spermatogenesis ( J:89030 )
• spermatozoa are absent from the vas deferens and epididymis instead the lumen of the epididymis contained many degenerating spermatocytes and some giant multi-nucleated cells

endocrine/exocrine glands
decreased testis weight ( J:89030 )
• combined testes weight in homozygotes is around half that in wild-type mice even though total body weights are not significantly different




Genotype
MGI:3039387
ht2
Allelic
Composition		 Ccna1tm1Coll/Ccna1+
Genetic
Background		 either: 129S/SvEv or (involves: 129S/SvEv * MF1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccna1tm1Coll mutation (0 available); any Ccna1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
oligozoospermia ( J:89030 )
• significantly fewer sperm are recovered from heterozygotes compared to wild-type mice
arrest of spermatogenesis ( J:89030 )
• pachytene spermatocytes are unaffected, while the number of haploid spermatids is significantly lower compared to wild-type mice
• Background Sensitivity: this affect is more pronounced on an inbred 129S6/SvEvTac background than on an outbred 129S6/SvEvTac x MF1 background
reduced male fertility ( J:89030 )
• the conception rate was reduced to 16% compared to 90% for wild-type mice
• on an inbred 129S6/SvEv background no offspring were obtained from heterozygous matings

cellular
oligozoospermia ( J:89030 )
• significantly fewer sperm are recovered from heterozygotes compared to wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory