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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Foxo3Gt(VICTR20)1Kca
gene trap 1, Karen C Arden
MGI:3038979
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Foxo3Gt(VICTR20)1Kca/Foxo3Gt(VICTR20)1Kca involves: 129S5/SvEvBrd * C57BL/6 MGI:3039402


Genotype
MGI:3039402
hm1
Allelic
Composition
Foxo3Gt(VICTR20)1Kca/Foxo3Gt(VICTR20)1Kca
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo3Gt(VICTR20)1Kca mutation (0 available); any Foxo3 mutation (51 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• females are infertile by the age of 10 weeks

endocrine/exocrine glands
• at 4.5 weeks mature follicles are much less common then in wild-type mice
• at 4.5 weeks growing follicles are prominent but mature follicles are much less common then in wild-type mice
• at 12 weeks no developing follicles are present

reproductive system
• at 9.5 weeks many oocytes have undergone degeneration indicating initiation of atretic change
• at 12 weeks all oocytes present have undergone degeneration
• at 4.5 weeks mature follicles are much less common then in wild-type mice
• at 4.5 weeks growing follicles are prominent but mature follicles are much less common then in wild-type mice
• at 12 weeks no developing follicles are present
• females are infertile by the age of 10 weeks

cellular
• at 9.5 weeks many oocytes have undergone degeneration indicating initiation of atretic change
• at 12 weeks all oocytes present have undergone degeneration





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory