mortality/aging
• females are infertile by the age of 10 weeks
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endocrine/exocrine glands
• at 4.5 weeks mature follicles are much less common then in wild-type mice
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• at 4.5 weeks growing follicles are prominent but mature follicles are much less common then in wild-type mice
• at 12 weeks no developing follicles are present
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reproductive system
• at 9.5 weeks many oocytes have undergone degeneration indicating initiation of atretic change
• at 12 weeks all oocytes present have undergone degeneration
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• at 4.5 weeks mature follicles are much less common then in wild-type mice
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• at 4.5 weeks growing follicles are prominent but mature follicles are much less common then in wild-type mice
• at 12 weeks no developing follicles are present
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• females are infertile by the age of 10 weeks
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cellular
• at 9.5 weeks many oocytes have undergone degeneration indicating initiation of atretic change
• at 12 weeks all oocytes present have undergone degeneration
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