Phenotypes associated with this allele

• Allele Symbol: Tg(Tec-BCR/ABL1)5Hhi
• Allele Name: transgene insertion 5, Hisamaru Hirai
• Allele ID: MGI:3039034
• Summary: 9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Dok1^tm1Ppp/Dok1^tm1Ppp Tg(Tec-BCR/ABL1)5Hhi/0	involves: 129S1/Sv	MGI:3574541
cx2	Dok2^tm1Ppp/Dok2^tm1Ppp Tg(Tec-BCR/ABL1)5Hhi/0	involves: 129S1/Sv	MGI:3574544
cx3	Dok1^tm1Ppp/Dok1^+ Tg(Tec-BCR/ABL1)5Hhi/0	involves: 129S1/Sv	MGI:3574545
cx4	Dok2^tm1Ppp/Dok2^+ Tg(Tec-BCR/ABL1)5Hhi/0	involves: 129S1/Sv	MGI:3574546
cx5	Dok1^tm1Yyam/Dok1^tm1Yyam Tg(Tec-BCR/ABL1)5Hhi/0	involves: C57BL/6	MGI:3574537
cx6	Dok1^tm1Yyam/Dok1^tm1Yyam Dok2^tm1Yyam/Dok2^tm1Yyam Tg(Tec-BCR/ABL1)5Hhi/0	involves: C57BL/6	MGI:3574538
cx7	Dok2^tm1Yyam/Dok2^tm1Yyam Tg(Tec-BCR/ABL1)5Hhi/0	involves: C57BL/6	MGI:3574539
cx8	Cbl^tm1Soga/Cbl^tm1Soga Tg(Tec-BCR/ABL1)5Hhi/0	involves: C57BL/6 * DBA/2	MGI:4354766
cx9	Cbl^tm1Soga/Cbl^+ Tg(Tec-BCR/ABL1)5Hhi/0	involves: C57BL/6 * DBA/2	MGI:4354767

Genotype
MGI:3574541

cx1

• Allelic Composition: Dok1^tm1Ppp/Dok1^tm1Ppp; Tg(Tec-BCR/ABL1)5Hhi/0
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:95334 )

• loss of Dok1 shortened lifespan to about 285 days from about 325 days in mice that are hemizygous for Tg(BCR/ABL1)5Hhi and wild-type for Dok1

neoplasm

increased leukemia incidence ( J:95334 )

• inactivation of Dok1 accelerated the onset of the chronic phase and the fatal blastic phase

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic myeloid leukemia		DOID:8552	OMIM:608232	J:95334

Genotype
MGI:3574544

cx2

• Allelic Composition: Dok2^tm1Ppp/Dok2^tm1Ppp; Tg(Tec-BCR/ABL1)5Hhi/0
• Genetic Background: involves: 129S1/Sv

mortality/aging

premature death ( J:95334 )

• loss of Dok2 shortened lifespan to about 270 days from about 321 days in mice that are hemizygous for Tg(BCR/ABL1)5Hhi and wild-type for Dok2

neoplasm

increased leukemia incidence ( J:95334 )

• inactivation of Dok2 accelerated the onset of the chronic phase and the fatal blastic phase

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic myeloid leukemia		DOID:8552	OMIM:608232	J:95334

Genotype
MGI:3574545

cx3

• Allelic Composition: Dok1^tm1Ppp/Dok1⁺; Tg(Tec-BCR/ABL1)5Hhi/0
• Genetic Background: involves: 129S1/Sv

mortality/aging

premature death ( J:95334 )

• loss of Dok1 shortened lifespan to about 307 days from about 325 days in mice that are hemizygous for Tg(BCR/ABL1)5Hhi and wild-type for Dok1

neoplasm

increased leukemia incidence ( J:95334 )

• inactivation of Dok1 accelerated the onset of the chronic phase and the fatal blastic phase

• acceleration was not as severe as in homozygous null mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic myeloid leukemia		DOID:8552	OMIM:608232	J:95334

Genotype
MGI:3574546

cx4

• Allelic Composition: Dok2^tm1Ppp/Dok2⁺; Tg(Tec-BCR/ABL1)5Hhi/0
• Genetic Background: involves: 129S1/Sv

mortality/aging

premature death ( J:95334 )

• loss of Dok2 shortened lifespan to about 283 days from about 321 days in mice that are hemizygous for Tg(BCR/ABL1)5Hhi and wild-type for Dok2

neoplasm

increased leukemia incidence ( J:95334 )

• inactivation of Dok2 accelerated the onset of the chronic phase and the fatal blastic phase

• acceleration was not as severe as in homozygous null mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic myeloid leukemia		DOID:8552	OMIM:608232	J:95334

Genotype
MGI:3574537

cx5

• Allelic Composition: Dok1^tm1Yyam/Dok1^tm1Yyam; Tg(Tec-BCR/ABL1)5Hhi/0
• Genetic Background: involves: C57BL/6

mortality/aging

premature death ( J:95335 )

• mutants begin to die at 4-5 months of age with few surviving beyond 6-9 months of age unlike mice hemizygous for Tg(BCR/ABL1)5Hhi which survive until 1 year of age

neoplasm

increased leukemia incidence ( J:95335 )

• severe blastic transformation is seen at 4-5 months of age with tumor cells composed of double positive immature T lymphoblasts

immune system

enlarged thymus ( J:95335 )

• enlarged thymus with massive infiltration of lymphoblasts seen at 4-5 months of age

enlarged lymph nodes ( J:95335 )

• enlarged lymph node with massive infiltration of lymphoblasts seen at 4-5 months of age

hematopoietic system

enlarged thymus ( J:95335 )

• enlarged thymus with massive infiltration of lymphoblasts seen at 4-5 months of age

endocrine/exocrine glands

enlarged thymus ( J:95335 )

• enlarged thymus with massive infiltration of lymphoblasts seen at 4-5 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic myeloid leukemia		DOID:8552	OMIM:608232	J:95335

Genotype
MGI:3574538

cx6

• Allelic Composition: Dok1^tm1Yyam/Dok1^tm1Yyam; Dok2^tm1Yyam/Dok2^tm1Yyam; Tg(Tec-BCR/ABL1)5Hhi/0
• Genetic Background: involves: C57BL/6

mortality/aging

premature death ( J:95335 )

• mutants begin to die at 4-5 months of age with few surviving beyond 6-9 months of age unlike mice hemizygous for Tg(BCR/ABL1)5Hhi which survive until 1 year of age

neoplasm

increased leukemia incidence ( J:95335 )

• severe blastic transformation is seen at 4-5 months of age with tumor cells composed of double positive immature T lymphoblasts

immune system

enlarged thymus ( J:95335 )

• enlarged thymus with massive infiltration of lymphoblasts seen at 4-5 months of age

enlarged lymph nodes ( J:95335 )

• enlarged lymph node with massive infiltration of lymphoblasts seen at 4-5 months of age

hematopoietic system

enlarged thymus ( J:95335 )

• enlarged thymus with massive infiltration of lymphoblasts seen at 4-5 months of age

endocrine/exocrine glands

enlarged thymus ( J:95335 )

• enlarged thymus with massive infiltration of lymphoblasts seen at 4-5 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic myeloid leukemia		DOID:8552	OMIM:608232	J:95335

Genotype
MGI:3574539

cx7

• Allelic Composition: Dok2^tm1Yyam/Dok2^tm1Yyam; Tg(Tec-BCR/ABL1)5Hhi/0
• Genetic Background: involves: C57BL/6

mortality/aging

premature death ( J:95335 )

• mutants begin to die at 4-5 months of age with few surviving beyond 6-9 months of age unlike mice hemizygous for Tg(BCR/ABL1)5Hhi which survive until 1 year of age

neoplasm

increased leukemia incidence ( J:95335 )

• severe blastic transformation is seen at 4-5 months of age with tumor cells composed of double positive immature T lymphoblasts

immune system

enlarged thymus ( J:95335 )

• enlarged thymus with massive infiltration of lymphoblasts seen at 4-5 months of age

enlarged lymph nodes ( J:95335 )

• enlarged lymph node with massive infiltration of lymphoblasts seen at 4-5 months of age

hematopoietic system

enlarged thymus ( J:95335 )

• enlarged thymus with massive infiltration of lymphoblasts seen at 4-5 months of age

endocrine/exocrine glands

enlarged thymus ( J:95335 )

• enlarged thymus with massive infiltration of lymphoblasts seen at 4-5 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic myeloid leukemia		DOID:8552	OMIM:608232	J:95335

Genotype
MGI:4354766

cx8

• Allelic Composition: Cbl^tm1Soga/Cbl^tm1Soga; Tg(Tec-BCR/ABL1)5Hhi/0
• Genetic Background: involves: C57BL/6 * DBA/2

mortality/aging

premature death ( J:151543 )

• all mice die by 41 weeks after birth with accelerated blast crisis compared to in Tg(BCR/ABL1)5Hhi mice

immune system

enlarged lymph nodes ( J:151543 )

• mice exhibit enlarged lymph nodes during blastic crisis with massive infiltrates of immature leukemic blasts

Genotype
MGI:4354767

cx9

• Allelic Composition: Cbl^tm1Soga/Cbl⁺; Tg(Tec-BCR/ABL1)5Hhi/0
• Genetic Background: involves: C57BL/6 * DBA/2

mortality/aging

premature death ( J:151543 )

• mice die prematurely with accelerated blast crisis compared to in Tg(BCR/ABL1)5Hhi mice