Phenotypes associated with this allele

• Allele Symbol: Tg(MMTV-Erbb2)10Pjo
• Allele Name: transgene insertion 10, Paul Jolicoeur
• Allele ID: MGI:3039039
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(MMTV-Erbb2)10Pjo/0	involves: BALB/c * C3H * C57BL/6	MGI:5604880

Genotype
MGI:5604880

tg1

• Allelic Composition: Tg(MMTV-Erbb2)10Pjo/0
• Genetic Background: involves: BALB/c * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased salivary gland tumor incidence ( J:72129 )

♀ • 5% of females develop a salivary gland tumor

increased mammary adenocarcinoma incidence ( J:72129 )

♀ • 44% of females, but no males, develop mammary tumors after 5-10 months of age

♀ • tumors are poorly differentiated typical adenocarcinomas, classified as Dunns type B adenocarcinoma

enlarged seminal vesicle ( J:72129 )

♂ • 100% of males exhibit seminal vesicle and epididymis enlargement; the seminal vesicles are either enlarged or of a reddish color and indurated and show focal papillary hyperplasia and hypertrophy of the epithelium

increased Harderian gland tumor incidence ( J:72129 )

• 5% of females and 8% of males exhibit unilateral proptosis; proptosis is due to a harderian gland tumor with severe bilateral hyperplasia and dysplasia of the epithelium

hematopoietic system

enlarged spleen ( J:72129 )

♀ • 100% of females, but not males, exhibit splenomegaly

increased spleen red pulp amount ( J:72129 )

♀ • red pulp is hypercellular and composed of immature elements of several lineages

immune system

enlarged spleen ( J:72129 )

♀ • 100% of females, but not males, exhibit splenomegaly

increased spleen red pulp amount ( J:72129 )

♀ • red pulp is hypercellular and composed of immature elements of several lineages

reproductive system

enlarged seminal vesicle ( J:72129 )

♂ • 100% of males exhibit seminal vesicle and epididymis enlargement; the seminal vesicles are either enlarged or of a reddish color and indurated and show focal papillary hyperplasia and hypertrophy of the epithelium

enlarged epididymis ( J:72129 )

♂ • 100% of males exhibit seminal vesicle and epididymis enlargement; the lumen of the epididymis is often extremely dilated and focal areas of papillary epithelial hyperplasia are seen

reduced male fertility ( J:72129 )

♂ • males are fertile in the first 2 months of age, but most become sterile by 3-4 months

neoplasm

increased salivary gland tumor incidence ( J:72129 )

♀ • 5% of females develop a salivary gland tumor

increased mammary adenocarcinoma incidence ( J:72129 )

♀ • 44% of females, but no males, develop mammary tumors after 5-10 months of age

♀ • tumors are poorly differentiated typical adenocarcinomas, classified as Dunns type B adenocarcinoma

increased Harderian gland tumor incidence ( J:72129 )

• 5% of females and 8% of males exhibit unilateral proptosis; proptosis is due to a harderian gland tumor with severe bilateral hyperplasia and dysplasia of the epithelium

vision/eye

exophthalmos ( J:72129 )

• 5% of females and 8% of males exhibit unilateral proptosis; proptosis is due to a harderian gland tumor with severe bilateral hyperplasia and dysplasia of the epithelium

integument

increased mammary adenocarcinoma incidence ( J:72129 )

♀ • 44% of females, but no males, develop mammary tumors after 5-10 months of age

♀ • tumors are poorly differentiated typical adenocarcinomas, classified as Dunns type B adenocarcinoma

growth/size/body

increased salivary gland tumor incidence ( J:72129 )

♀ • 5% of females develop a salivary gland tumor

enlarged spleen ( J:72129 )

♀ • 100% of females, but not males, exhibit splenomegaly

digestive/alimentary system

increased salivary gland tumor incidence ( J:72129 )

♀ • 5% of females develop a salivary gland tumor

craniofacial

increased salivary gland tumor incidence ( J:72129 )

♀ • 5% of females develop a salivary gland tumor

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:72129