Analysis Tools
liver/biliary system
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• mice by 1 month of age and continuing through 12 months of age have liver weights that are greater than 10% of the total body weight
• by 17 months of age, 50% of male mice have liver weights that are over half the total body weight
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• frequent mitotic bodies and dysplastic cell nuclei are evident in males under 6 months of age
• nuclear shapes are highly irregular, forming notched shapes, slipper shapes, and in some cases a dumbbell shape that suggest incomplete mitosis
• some abnormally large hepatocytes contain large nucleoli, nuclear and cytoplasmic inclusions, glycogen bodies, and clumped cytoplasmic material suggestive of Mallory's hyaline
• tripolar mitotic bodies are also evident
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• some abnormally large hepatocytes contain large nucleoli, nuclear and cytoplasmic inclusions, glycogen bodies, and clumped cytoplasmic material suggestive of Mallory's hyaline
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• by 12 months of age, multifocal eosinophilic and clear cell nodules are apparent in about half of male but not female mice
• nodules typically ranged in size from 1-2 mm in diameter at 12 months of age
• by 17 months age, 75% of male mice have adenomas while none is observed in female mice
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neoplasm
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• by 12 months of age, multifocal eosinophilic and clear cell nodules are apparent in about half of male but not female mice
• nodules typically ranged in size from 1-2 mm in diameter at 12 months of age
• by 17 months age, 75% of male mice have adenomas while none is observed in female mice
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growth/size/body
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• mice by 1 month of age and continuing through 12 months of age have liver weights that are greater than 10% of the total body weight
• by 17 months of age, 50% of male mice have liver weights that are over half the total body weight
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