All Phenotypes Trp53<tm3.1Tyj> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Trp53^tm3.1Tyj
targeted mutation 3.1, Tyler Jacks
MGI:3039266

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Trp53^tm3.1Tyj/Trp53⁺	involves: 129S4/SvJae	MGI:3584470
ht2	Trp53^tm3.1Tyj/Trp53⁺	involves: 129S4/SvJae * SKH1	MGI:3716949
ht3	Trp53^tm1Tyj/Trp53^tm3.1Tyj	involves: 129S2/SvPas * 129S4/SvJae	MGI:3584471
cn4	Braf^tm1Mmcm/Braf⁺ Trp53^tm1Brn/Trp53^tm3.1Tyj Tg(TPO-cre/ERT2)1139Tyj/0	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac	MGI:5897858
cn5	Braf^tm1Mmcm/Braf⁺ Trp53^tm3.1Tyj/Trp53⁺ Tg(TPO-cre/ERT2)1139Tyj/0	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac	MGI:5897857
cn6	Csnk1a1^tm1.1Ybn/Csnk1a1^tm1.1Ybn Tg(Vil1-cre/ERT2)23Syr/0 Trp53^tm3.1Tyj/Trp53^tm3.1Tyj	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * DBA/2	MGI:6448987
cn7	Kras^tm1.1Khai/Kras⁺ Tg(Pdx1-cre)6Tuv/0 Trp53^tm3.1Tyj/Trp53⁺	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:6505559
cn8	Kras^tm4Tyj/Kras⁺ Tg(Pdx1-cre)6Tuv/0 Trp53^tm3.1Tyj/Trp53⁺	involves: 129S4/SvJae * C57BL/6 * FVB/N	MGI:6505560

Allelic Composition	Trp53^tm3.1Tyj/Trp53⁺
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53^tm3.1Tyj mutation (2 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:95316 )

• mean life span is 15.8 months

neoplasm

increased metastatic potential ( J:95316 )

• compared to Trp53^tm1Tyj

increased tumor incidence ( J:95316 )

increased B cell derived lymphoma incidence ( J:95316 )

• 5 of 36 develop B cell lymphomas generally arising in the spleen or mesenteric lymph nodes

increased carcinoma incidence ( J:95316 )

• the incidence of carcinomas is increased compared to Trp53^tm1Tyj heterozygotes

• 5 of 36 develop squamous cell carcinomas and a single case each of transitional cell renal carcinoma and intestinal carcinoma are seen

increased hepatocellular carcinoma incidence ( J:95316 )

• 2 of 36 develop hepatocellular carcinomas

increased lung adenocarcinoma incidence ( J:95316 )

• 7 of 36 develop lung adenocarcinomas, several with malignant features commonly seen in human lung adenocarcinoma including nuclear atypia (5 of 7), desmoplasia (4 of 7), and metaplasias (2 of 7)

increased squamous cell carcinoma incidence ( J:95316 )

• 5 of 36 develop squamous cell carcinomas

cellular

decreased cellular sensitivity to gamma-irradiation ( J:95316 )

• resistance to gamma-irradiation induced apoptosis is increased compared to Trp53^tm1Tyj hterozygotes

increased cell proliferation ( J:95316 )

• a larger fraction of MEFs are in S phase compared to Trp53^tm1Tyj hterozygotes; however DNA damage-induced G1 arrest is intact

respiratory system

increased lung adenocarcinoma incidence ( J:95316 )

• 7 of 36 develop lung adenocarcinomas, several with malignant features commonly seen in human lung adenocarcinoma including nuclear atypia (5 of 7), desmoplasia (4 of 7), and metaplasias (2 of 7)

liver/biliary system

increased hepatocellular carcinoma incidence ( J:95316 )

• 2 of 36 develop hepatocellular carcinomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Li-Fraumeni syndrome		DOID:3012	OMIM:PS151623	J:95316

Allelic Composition	Trp53^tm3.1Tyj/Trp53⁺
Genetic Background	involves: 129S4/SvJae * SKH1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53^tm3.1Tyj mutation (2 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:121734 )

• in 2 mice

increased skin tumor incidence ( J:121734 )

• whether spontaneous or induced, mice develop epithelial, proliferative lesions forming a continuum from nonneoplastic squamous keratosis and acanthosis to squamous cell papillomas, actinic keratosis and keratoacanthoma with increasing degrees of atypia and dysplasia, carcinoma in situ, up to invasive squamous cell carcinoma

integument

increased mammary adenocarcinoma incidence ( J:121734 )

• in 2 mice

increased skin tumor incidence ( J:121734 )

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:121734 )

• in 2 mice

Allelic Composition	Trp53^tm1Tyj/Trp53^tm3.1Tyj
Genetic Background	involves: 129S2/SvPas * 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (240 available)
Trp53^tm3.1Tyj mutation (2 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:95316 )

• mean life span is 4.6 months

prenatal lethality, incomplete penetrance ( J:95316 )

• a slight decrease is seen in the number of females born

neoplasm

increased tumor incidence ( J:95316 )

• 43% have multiple tumors

increased T cell derived lymphoma incidence ( J:95316 )

• a slight decrease in hematological malignancies (primarily T cell lymphomas) is seen compared to Trp53^tm1Tyj homozygotes (55% compared to 66%)

increased carcinoma incidence ( J:95316 )

• carcinomas are seen in 18% of mice, with most carcinomas showing signs of invasion, metastasis, or other features of advanced human carcinomas

• most carcinomas are derived from epithelial cells

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:95316 )

• a slight decrease in hematological malignancies (primarily T cell lymphomas) is seen compared to Trp53^tm1Tyj homozygotes (55% compared to 66%)

immune system

increased T cell derived lymphoma incidence ( J:95316 )

• a slight decrease in hematological malignancies (primarily T cell lymphomas) is seen compared to Trp53^tm1Tyj homozygotes (55% compared to 66%)

hematopoietic system

increased T cell derived lymphoma incidence ( J:95316 )

• a slight decrease in hematological malignancies (primarily T cell lymphomas) is seen compared to Trp53^tm1Tyj homozygotes (55% compared to 66%)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Li-Fraumeni syndrome		DOID:3012	OMIM:PS151623	J:95316

Allelic Composition	Braf^tm1Mmcm/Braf⁺ Trp53^tm1Brn/Trp53^tm3.1Tyj Tg(TPO-cre/ERT2)1139Tyj/0
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braf^tm1Mmcm mutation (3 available); any Braf mutation (60 available)
Tg(TPO-cre/ERT2)1139Tyj mutation (1 available)
Trp53^tm1Brn mutation (18 available); any Trp53 mutation (240 available)
Trp53^tm3.1Tyj mutation (2 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased thyroid carcinoma incidence ( J:208854 )

• tamoxifen treated mice exhibit accelerated progression to poorly differentiated thyroid carcinoma and overt undifferentiated anaplastic thyroid carcinoma with highly pleomorphic, atypical cells with evidence of necrosis

neoplasm

increased thyroid carcinoma incidence ( J:208854 )

Allelic Composition	Braf^tm1Mmcm/Braf⁺ Trp53^tm3.1Tyj/Trp53⁺ Tg(TPO-cre/ERT2)1139Tyj/0
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braf^tm1Mmcm mutation (3 available); any Braf mutation (60 available)
Tg(TPO-cre/ERT2)1139Tyj mutation (1 available)
Trp53^tm3.1Tyj mutation (2 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:208854 )

• tamoxifen treated mice exhibit shortened survival

endocrine/exocrine glands

increased thyroid carcinoma incidence ( J:208854 )

• tamoxifen treated mice develop large papillary thyroid carcinoma that exhibit features associated with aggressive behavior including solid growth, tall cell morphology, focal necrosis, and hobnail features

• about 50% of mice with papillary thyroid carcinoma acquire poorly differentiated thyroid carcinoma or undifferentiated anaplastic thyroid carcinoma

neoplasm

increased thyroid carcinoma incidence ( J:208854 )

• about 50% of mice with papillary thyroid carcinoma acquire poorly differentiated thyroid carcinoma or undifferentiated anaplastic thyroid carcinoma

Allelic Composition	Csnk1a1^tm1.1Ybn/Csnk1a1^tm1.1Ybn Tg(Vil1-cre/ERT2)23Syr/0 Trp53^tm3.1Tyj/Trp53^tm3.1Tyj
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csnk1a1^tm1.1Ybn mutation (1 available); any Csnk1a1 mutation (38 available)
Tg(Vil1-cre/ERT2)23Syr mutation (1 available)
Trp53^tm3.1Tyj mutation (2 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal enterocyte proliferation ( J:291671 )

• increased proliferation in the colon and ileum, but not the duodenum and jejunum

abnormal enterocyte morphology ( J:291671 )

• dysplastic in the colon and ileum, but not the duodenum and jejunum

cellular

abnormal enterocyte proliferation ( J:291671 )

• increased proliferation in the colon and ileum, but not the duodenum and jejunum

Allelic Composition	Kras^tm1.1Khai/Kras⁺ Tg(Pdx1-cre)6Tuv/0 Trp53^tm3.1Tyj/Trp53⁺
Genetic Background	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm1.1Khai mutation (1 available); any Kras mutation (84 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
Trp53^tm3.1Tyj mutation (2 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased pancreatic ductal adenocarcinoma incidence ( J:276349 )

• 9 of 12 mice develop pancreatic tumors; all cancers are invasive pancreatic ductal adenocarcinoma

mortality/aging

premature death ( J:276349 )

• median lifespan is approximately 120 days with all mice dying around 260 days, which is extended survival compared to conditional mice expressing the Kras^tm4Tyj allele

endocrine/exocrine glands

increased pancreatic ductal adenocarcinoma incidence ( J:276349 )

• 9 of 12 mice develop pancreatic tumors; all cancers are invasive pancreatic ductal adenocarcinoma

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic ductal adenocarcinoma		DOID:3498		J:276349

Allelic Composition	Kras^tm4Tyj/Kras⁺ Tg(Pdx1-cre)6Tuv/0 Trp53^tm3.1Tyj/Trp53⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm4Tyj mutation (9 available); any Kras mutation (84 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
Trp53^tm3.1Tyj mutation (2 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased pancreatic ductal adenocarcinoma incidence ( J:276349 )

• all mice develop pancreatic tumors; all cancers are invasive pancreatic ductal adenocarcinoma

mortality/aging

premature death ( J:276349 )

• median lifespan is approximately 70 days, with all mice dying around 120 days

endocrine/exocrine glands

increased pancreatic ductal adenocarcinoma incidence ( J:276349 )

• all mice develop pancreatic tumors; all cancers are invasive pancreatic ductal adenocarcinoma

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic ductal adenocarcinoma		DOID:3498		J:276349

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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