Analysis Tools
behavior/neurological
polydipsia
(
J:89252
)
|
• transgenic mice drink significantly more than non-transgenic mice
|
cardiovascular system
hypertension
(
J:89252
)
|
• transgenic mice have blood pressures more than 25 mmHg higher than wild-type mice
• administration of an angiotensin II receptor antagonist lowered blood pressure in transgenic mice down to that seen in wild-type mice
|
homeostasis/metabolism
|
• serum creatinine is elevated in transgenic mice
|
|
• transgenic mice produce dilute urine but are able to produce concentrated urine following water deprivation
|
albuminuria
(
J:89252
)
|
• urine protein/creatinine ratios are elevated and an increase in albumin in the urine of transgenic mice is seen
• administration of an angiotensin II receptor antagonist improved this condition
|
immune system
|
• vascular, glomerular, and tubointerstitial changes indicative of hypertensive nephrosclerosis are seen in transgenic mice
• cortical sections show inflammatory infiltrates, fibroid necrosis and arterial disruption
• administration of an angiotensin II receptor antagonist ameliorated these pathological changes
|
renal/urinary system
|
• transgenic mice produce dilute urine but are able to produce concentrated urine following water deprivation
|
albuminuria
(
J:89252
)
|
• urine protein/creatinine ratios are elevated and an increase in albumin in the urine of transgenic mice is seen
• administration of an angiotensin II receptor antagonist improved this condition
|
|
• vascular, glomerular, and tubointerstitial changes indicative of hypertensive nephrosclerosis are seen in transgenic mice
• cortical sections show inflammatory infiltrates, fibroid necrosis and arterial disruption
• administration of an angiotensin II receptor antagonist ameliorated these pathological changes
|
