Phenotypes associated with this allele

• Allele Symbol: Tg(Alb1-Ren)2Unc
• Allele Name: transgene insertion 2, University of North Carolina
• Allele ID: MGI:3039271
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Adm^tm1Unc/Adm^+ Tg(Alb1-Ren)2Unc/?	129S6/SvEvTac-Adm^tm1Unc Tg(Alb1-Ren)2Unc	MGI:3763615
tg2	Tg(Alb1-Ren)2Unc/0	involves: 129S6/SvEvTac * C57BL/6	MGI:3039512
tg3	Tg(Alb1-Ren)2Unc/?	129S6/SvEvTac-Tg(Alb1-Ren)2Unc	MGI:3763616

Genotype
MGI:3763615

cx1

• Allelic Composition: Adm^tm1Unc/Adm⁺; Tg(Alb1-Ren)2Unc/?
• Genetic Background: 129S6/SvEvTac-Adm^tm1Unc Tg(Alb1-Ren)2Unc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased myocardial fiber size ( J:125933 )

• male cardiomyocytes are larger than in Tg(Alb1-Ren)1Unc male mice

• however, there is no difference in cardiomyocyte size in female mice compared to Tg(Alb1-Ren)1Unc female mice

cardiac hypertrophy ( J:125933 )

• male mice exhibit increased cardiac hypertrophy compared to Tg(Alb1-Ren)1Unc male mice

• however, female mice are not significantly different in terms of cardiac hypertrophy compared to female mice containing Tg(Alb1-Ren)1Unc and the degree of coronary artery fibrosis is the same as in Tg(Alb1-Ren)1Unc mice regardless of gender

increased systemic arterial blood pressure ( J:125933 )

• 149+/-12 mmHg compared to 108+/-9 mmHg in wild-type mice

• however, blood pressure is not significantly different from Tg(Alb1-Ren)1Unc containing mice

renal/urinary system

glomerulosclerosis ( J:125933 )

• glomerulosclerosis is worse in male mice than in Tg(Alb1-Ren)1Unc male mice

• however, there is no difference in glomerulosclerosis in female mice compared to Tg(Alb1-Ren)1Unc female mice

renal cast ( J:125933 )

• presence of proteinacious casts is worse in male mice than in Tg(Alb1-Ren)1Unc male mice

• however, there is no difference in presence of proteinacious casts in female mice compared to Tg(Alb1-Ren)1Unc female mice

renal fibrosis ( J:125933 )

• renal fibrosis is worse in male mice than in Tg(Alb1-Ren)1Unc male mice

• however, there is no difference in renal fibrosis in female mice compared to Tg(Alb1-Ren)1Unc female mice

muscle

increased myocardial fiber size ( J:125933 )

• male cardiomyocytes are larger than in Tg(Alb1-Ren)1Unc male mice

• however, there is no difference in cardiomyocyte size in female mice compared to Tg(Alb1-Ren)1Unc female mice

growth/size/body

cardiac hypertrophy ( J:125933 )

• male mice exhibit increased cardiac hypertrophy compared to Tg(Alb1-Ren)1Unc male mice

• however, female mice are not significantly different in terms of cardiac hypertrophy compared to female mice containing Tg(Alb1-Ren)1Unc and the degree of coronary artery fibrosis is the same as in Tg(Alb1-Ren)1Unc mice regardless of gender

Genotype
MGI:3039512

tg2

• Allelic Composition: Tg(Alb1-Ren)2Unc/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

mortality/aging

premature death ( J:88650 )

• about 60% of transgenic males die suddenly between 6 and 8 months of age

behavior/neurological

polydipsia ( J:89252 )

• transgenic mice drink significantly more than non-transgenic mice

cardiovascular system

cardiac hypertrophy ( J:88650 )

• transgenic mice have: increased left ventricle/body weight ratios; increased cardiac myocyte cross-sectional area; generalized fibrosis; decreased left ventricular end systolic dimension coupled with increased cardiac function, indicating that these mice have concentric hypertrophy, without ventricular dilation or overt heart failure

decreased heart rate ( J:88650 )

• in mice that die prematurely a prolonged and progressive bradycardia is seen

• transgenics show a significant decrease in heart rate variability compared to wild-type mice

hypertension ( J:88650 , J:89252 )

• transgenic mice have blood pressures more than 25 mmHg higher than wild-type mice (J:88650)

• transgenic mice have blood pressures more than 25 mmHg higher than wild-type mice (J:89252)

• administration of an angiotensin II receptor antagonist lowered blood pressure in transgenic mice down to that seen in wild-type mice (J:89252)

homeostasis/metabolism

increased circulating creatinine level ( J:89252 )

• serum creatinine is elevated in transgenic mice

decreased urine osmolality ( J:89252 )

• transgenic mice produce dilute urine but are able to produce concentrated urine following water deprivation

albuminuria ( J:89252 )

• urine protein/creatinine ratios are elevated and an increase in albumin in the urine of transgenic mice is seen

• administration of an angiotensin II receptor antagonist improved this condition

immune system

kidney inflammation ( J:89252 )

• vascular, glomerular, and tubointerstitial changes indicative of hypertensive nephrosclerosis are seen in transgenic mice

• cortical sections show inflammatory infiltrates, fibroid necrosis and arterial disruption

• administration of an angiotensin II receptor antagonist ameliorated these pathological changes

renal/urinary system

decreased urine osmolality ( J:89252 )

• transgenic mice produce dilute urine but are able to produce concentrated urine following water deprivation

albuminuria ( J:89252 )

• urine protein/creatinine ratios are elevated and an increase in albumin in the urine of transgenic mice is seen

• administration of an angiotensin II receptor antagonist improved this condition

kidney inflammation ( J:89252 )

• vascular, glomerular, and tubointerstitial changes indicative of hypertensive nephrosclerosis are seen in transgenic mice

• cortical sections show inflammatory infiltrates, fibroid necrosis and arterial disruption

• administration of an angiotensin II receptor antagonist ameliorated these pathological changes

polyuria ( J:89252 )

growth/size/body

cardiac hypertrophy ( J:88650 )

• transgenic mice have: increased left ventricle/body weight ratios; increased cardiac myocyte cross-sectional area; generalized fibrosis; decreased left ventricular end systolic dimension coupled with increased cardiac function, indicating that these mice have concentric hypertrophy, without ventricular dilation or overt heart failure

Genotype
MGI:3763616

tg3

• Allelic Composition: Tg(Alb1-Ren)2Unc/?
• Genetic Background: 129S6/SvEvTac-Tg(Alb1-Ren)2Unc

cardiovascular system

increased systemic arterial blood pressure ( J:125933 )

• 145+/-8 mmHg compared to 108+/-9 mmHg in wild-type mice