Phenotypes associated with this allele

• Allele Symbol: Sell^tm1Flv
• Allele Name: targeted mutation 1, Richard A Flavell
• Allele ID: MGI:3039283
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sell^tm1Flv/Sell^tm1Flv	involves: 129S2/SvPas * C57BL/6	MGI:3039425
hm2	Sell^tm1Flv/Sell^tm1Flv	involves: C57BL/6 * NOD	MGI:3039428
hm3	Sell^tm1Flv/Sell^tm1Flv	NOD.Cg-Sell^tm1Flv	MGI:3039435
ht4	Sell^tm1Flv/Sell^+	involves: C57BL/6 * NOD	MGI:3039434
ht5	Sell^tm1Flv/Sell^+	NOD.Cg-Sell^tm1Flv	MGI:3039437

Genotype
MGI:3039425

hm1

• Allelic Composition: Sell^tm1Flv/Sell^tm1Flv
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased activated T cell number ( J:89253 )

• following subcutaneous immunization with keyhole limpet hemocyanin/complete Freund's adjuvant (KLH/CFA) emulsion the number of lymphocytes from draining lymph nodes is significantly decreased compared to wild-type controls

• 5 days after immunization keyhole limpet hemocyanin-specific T-cell proliferative response in draining lymph nodes is dramatically decreased

• 9 days after immunization keyhole limpet hemocyanin-specific T-cell proliferative response in draining lymph nodes is restored to that in wild-type controls

abnormal type IV hypersensitivity reaction ( J:89253 )

• 4 days after KLH/CFA immunization the delayed type hypersensitivity responses are dramatically reduced in mutants compared to wild-type mice as a result of deficient T cell priming

hematopoietic system

decreased activated T cell number ( J:89253 )

• following subcutaneous immunization with keyhole limpet hemocyanin/complete Freund's adjuvant (KLH/CFA) emulsion the number of lymphocytes from draining lymph nodes is significantly decreased compared to wild-type controls

• 5 days after immunization keyhole limpet hemocyanin-specific T-cell proliferative response in draining lymph nodes is dramatically decreased

• 9 days after immunization keyhole limpet hemocyanin-specific T-cell proliferative response in draining lymph nodes is restored to that in wild-type controls

Genotype
MGI:3039428

hm2

• Allelic Composition: Sell^tm1Flv/Sell^tm1Flv
• Genetic Background: involves: C57BL/6 * NOD

endocrine/exocrine glands

pancreas inflammation ( J:88947 )

• inflammation of the islet of Langerhans is seen by 9 weeks in mutant and wild-type mice

immune system

pancreas inflammation ( J:88947 )

• inflammation of the islet of Langerhans is seen by 9 weeks in mutant and wild-type mice

decreased susceptibility to autoimmune disorder ( J:88947 )

• adoptive transfer experiment results with mutants backcrossed to NOD for 10 or more generations indicate that this reduction is a result of incomplete NOD genetic background

• the incidence of diabetes in these mutants is also decreased as a result of incomplete NOD genetic background

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:88974

Genotype
MGI:3039435

hm3

• Allelic Composition: Sell^tm1Flv/Sell^tm1Flv
• Genetic Background: NOD.Cg-Sell^tm1Flv

immune system

immune system phenotype ( J:88974 )

N • no difference in the incidence of diabetes is seen between mutant and wild-type NOD mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:88974

Genotype
MGI:3039434

ht4

• Allelic Composition: Sell^tm1Flv/Sell⁺
• Genetic Background: involves: C57BL/6 * NOD

endocrine/exocrine glands

pancreas inflammation ( J:88947 )

• inflammation of the islet of Langerhans is seen by 9 weeks in heterozygous and wild-type mice

immune system

pancreas inflammation ( J:88947 )

• inflammation of the islet of Langerhans is seen by 9 weeks in heterozygous and wild-type mice

decreased susceptibility to autoimmune diabetes ( J:88947 )

• the incidence of diabetes (blood glucose >250 mg/dl) in these heterozygotes is decreased as a result of incomplete NOD genetic background

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:88974

Genotype
MGI:3039437

ht5

• Allelic Composition: Sell^tm1Flv/Sell⁺
• Genetic Background: NOD.Cg-Sell^tm1Flv

immune system

immune system phenotype ( J:88974 )

N • no difference in the incidence of diabetes (blood glucose >250 mg/dl) is seen between heterozygous and wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:88974