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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Crlf2tm1Jni
targeted mutation 1, James N Ihle
MGI:3039288
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Crlf2tm1Jni/Crlf2tm1Jni involves: 129P2/OlaHsd MGI:5438832
hm2
 		Crlf2tm1Jni/Crlf2tm1Jni involves: 129P2/OlaHsd * C57BL/6 MGI:3039553
cx3
 		Jak3tm1Jni/Jak3tm1Jni
Crlf2tm1Jni/Crlf2tm1Jni 		involves: 129P2/OlaHsd * C57BL/6 MGI:3039555


Genotype
MGI:5438832
hm1
Allelic
Composition		 Crlf2tm1Jni/Crlf2tm1Jni
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crlf2tm1Jni mutation (0 available); any Crlf2 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
respiratory system inflammation ( J:187770 )
• LPS-stimulated dendritic cells transferred into wild-type mice exhibit neutrophil-dominant airway inflammation compared with an eosinophil-dominant infiltration induced by wild-type dendritic cells

respiratory system
respiratory system inflammation ( J:187770 )
• LPS-stimulated dendritic cells transferred into wild-type mice exhibit neutrophil-dominant airway inflammation compared with an eosinophil-dominant infiltration induced by wild-type dendritic cells




Genotype
MGI:3039553
hm2
Allelic
Composition		 Crlf2tm1Jni/Crlf2tm1Jni
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crlf2tm1Jni mutation (0 available); any Crlf2 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:89031 )
N
• normal hematological parameters and hematopoietic cell development

immune system
immune system phenotype ( J:89031 )
N
• normal thymus, spleen, and lymph node morphology
• normal B and T cell development




Genotype
MGI:3039555
cx3
Allelic
Composition		 Jak3tm1Jni/Jak3tm1Jni
Crlf2tm1Jni/Crlf2tm1Jni
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crlf2tm1Jni mutation (0 available); any Crlf2 mutation (21 available)
Jak3tm1Jni mutation (0 available); any Jak3 mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B cell number ( J:89031 )
• loss of the residual splenic B220+ lymphoctyte population that persists in Jak3tm1Jni homozygotes

immune system
decreased B cell number ( J:89031 )
• loss of the residual splenic B220+ lymphoctyte population that persists in Jak3tm1Jni homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory