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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Efnb1tm1Sor
targeted mutation 1, Philippe Soriano
MGI:3039289
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Efnb1tm1Sor/Efnb1+
Meox2tm1(cre)Sor/Meox2+ 		involves: 129S4/SvJaeSor MGI:3719103
cn2
 		Efnb1tm1Sor/Y
Meox2tm1(cre)Sor/Meox2+ 		involves: 129S4/SvJaeSor MGI:3719101
cn3
 		Efnb1tm1Sor/Efnb1tm1Sor
Meox2tm1(cre)Sor/Meox2+ 		involves: 129S4/SvJaeSor MGI:3719100
cn4
 		Efnb1tm1Sor/Y
Meox2tm1(cre)Sor/Meox2+ 		involves: 129S4/SvJaeSor * C57BL/6 MGI:3719099
cn5
 		Efnb1tm1Sor/Efnb1+
Meox2tm1(cre)Sor/Meox2+ 		involves: 129S4/SvJaeSor * C57BL/6 MGI:3719102
cn6
 		Efnb1tm1Sor/Efnb1+
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: 129S4/SvJaeSor * C57BL/6 * CBA MGI:3719104


Genotype
MGI:3719103
cn1
Allelic
Composition		 Efnb1tm1Sor/Efnb1+
Meox2tm1(cre)Sor/Meox2+
Genetic
Background		 involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb1tm1Sor mutation (1 available); any Efnb1 mutation (15 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:89008 )
• less than Mendelian ratios of mice are recovered at 2 weeks after birth

limbs/digits/tail
polydactyly ( J:89008 )
• 100% of mice have polydactyly restricted to digits I or II of either the hindlimbs or forelimbs
• Background Sensitivity: on the 129S4/SvJaeSor background defects are restricted to only the last phalange




Genotype
MGI:3719101
cn2
Allelic
Composition		 Efnb1tm1Sor/Y
Meox2tm1(cre)Sor/Meox2+
Genetic
Background		 involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb1tm1Sor mutation (1 available); any Efnb1 mutation (15 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:89008 )
• less than Mendelian ratios of mice are recovered at 2 weeks after birth
• Background Sensitivity: postnatal lethality is more severe in a 129S4/SvJaeSor background than in a mixed 129S4/SvJaeSor C57BL/6 background




Genotype
MGI:3719100
cn3
Allelic
Composition		 Efnb1tm1Sor/Efnb1tm1Sor
Meox2tm1(cre)Sor/Meox2+
Genetic
Background		 involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb1tm1Sor mutation (1 available); any Efnb1 mutation (15 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:89008 )
• less than Mendelian ratios of mice are recovered at 2 weeks after birth




Genotype
MGI:3719099
cn4
Allelic
Composition		 Efnb1tm1Sor/Y
Meox2tm1(cre)Sor/Meox2+
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb1tm1Sor mutation (1 available); any Efnb1 mutation (15 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:89008 )
• less than Mendelian ratios of mice are recovered at 2 weeks after birth
• Background Sensitivity: postnatal lethality is more severe in a 129S4/SvJaeSor background than in a mixed 129S4/SvJaeSor C57BL/6 background




Genotype
MGI:3719102
cn5
Allelic
Composition		 Efnb1tm1Sor/Efnb1+
Meox2tm1(cre)Sor/Meox2+
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb1tm1Sor mutation (1 available); any Efnb1 mutation (15 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:89008 )
• less than Mendelian ratios of mice are recovered at 2 weeks after birth

limbs/digits/tail
polydactyly ( J:89008 )
• 100% of mice have polydactyly restricted to digits I or II of either the hindlimbs or forelimbs

skeleton
abnormal perichondrium morphology ( J:89008 )
• the perichondrium around forming digits is poorly organized




Genotype
MGI:3719104
cn6
Allelic
Composition		 Efnb1tm1Sor/Efnb1+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb1tm1Sor mutation (1 available); any Efnb1 mutation (15 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
cleft palate ( J:89008 )
• in 15% of mice
failure of palatal shelf elevation ( J:89008 )
• at E14.5, palatal shelves fail to elevate

hearing/vestibular/ear
abnormal tympanic ring morphology ( J:89008 )
• bilaterally defective

digestive/alimentary system
cleft palate ( J:89008 )
• in 15% of mice
failure of palatal shelf elevation ( J:89008 )
• at E14.5, palatal shelves fail to elevate

growth/size/body
cleft palate ( J:89008 )
• in 15% of mice
failure of palatal shelf elevation ( J:89008 )
• at E14.5, palatal shelves fail to elevate




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory