Phenotypes associated with this allele

• Allele Symbol: Cdkn1a^{tm1(HBsAg)Xya}
• Allele Name: targeted mutation 1, Xiao Yang
• Allele ID: MGI:3039362
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdkn1a^tm1(HBsAg)Xya/Cdkn1a^tm1(HBsAg)Xya	either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss)	MGI:3046807
ht2	Cdkn1a^tm1(HBsAg)Xya/Cdkn1a^+	either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss)	MGI:3046834

Genotype
MGI:3046807

hm1

• Allelic Composition: Cdkn1a^{tm1(HBsAg)Xya}/Cdkn1a^{tm1(HBsAg)Xya}
• Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased hepatocellular carcinoma incidence ( J:88078 )

• hepatocellular carcinoma (HCC) observed in 72.7% of male mice between 15 and 24 months of age, but not in any female mice of the same age

• no metastases were detected

• HCC was multifocal with most mice exhibiting1 to 2 highly vascularized large tumors (0.5 to 2.5 cm) and many smaller tumors distributed throughout

• moderately well-differentiated HCC were made of eosinophilic cells and compressed the neighboring non-tumorous liver parenchyma

liver/biliary system

hepatic steatosis ( J:88078 )

• observed in some mice

increased hepatocellular carcinoma incidence ( J:88078 )

• hepatocellular carcinoma (HCC) observed in 72.7% of male mice between 15 and 24 months of age, but not in any female mice of the same age

• no metastases were detected

• HCC was multifocal with most mice exhibiting1 to 2 highly vascularized large tumors (0.5 to 2.5 cm) and many smaller tumors distributed throughout

• moderately well-differentiated HCC were made of eosinophilic cells and compressed the neighboring non-tumorous liver parenchyma

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:88078

Genotype
MGI:3046834

ht2

• Allelic Composition: Cdkn1a^{tm1(HBsAg)Xya}/Cdkn1a⁺
• Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss)

neoplasm

increased hepatocellular carcinoma incidence ( J:88078 )

• hepatocellular carcinoma (HCC) observed in 53.3% of male mice between 15 and 24 months of age, but not in any female mice of the same age

• no metastases were detected

• HCC was multifocal with most mice exhibiting1 to 2 highly vascularized large tumors (0.5 to 2.5 cm) and many smaller tumors distributed throughout

• moderately well-differentiated HCC were made of eosinophilic cells and compressed the neighboring non-tumorous liver parenchyma

liver/biliary system

hepatic steatosis ( J:88078 )

• observed in some mice

increased hepatocellular carcinoma incidence ( J:88078 )

• hepatocellular carcinoma (HCC) observed in 53.3% of male mice between 15 and 24 months of age, but not in any female mice of the same age

• no metastases were detected

• HCC was multifocal with most mice exhibiting1 to 2 highly vascularized large tumors (0.5 to 2.5 cm) and many smaller tumors distributed throughout

• moderately well-differentiated HCC were made of eosinophilic cells and compressed the neighboring non-tumorous liver parenchyma

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:88078