Phenotypes associated with this allele

• Allele Symbol: Cdkn1a^tm2(HBx)Xya
• Allele Name: targeted mutation 2, Xiao Yang
• Allele ID: MGI:3039363
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdkn1a^tm2(HBx)Xya/Cdkn1a^tm2(HBx)Xya	either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss)	MGI:3046808
ht2	Cdkn1a^tm2(HBx)Xya/Cdkn1a^+	either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss)	MGI:3046835

Genotype
MGI:3046808

hm1

• Allelic Composition: Cdkn1a^tm2(HBx)Xya/Cdkn1a^tm2(HBx)Xya
• Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased hepatocellular carcinoma incidence ( J:88078 )

• hepatocellular carcinoma (HCC) observed in 63.6% of male mice and in 42.9% of female mice after 18 months of age

• no metastases were detected

• HCC was multifocal with most mice exhibiting1 to 2 highly vascularized large tumors (0.5 to 2.5 cm) and many smaller tumors distributed throughout

• HCC compressing adjacent normal hepatocytes observed after 18 months of age and typically associated with fatty liver and inflammation

liver/biliary system

hepatic steatosis ( J:88078 )

• observed in some mice

increased hepatocellular carcinoma incidence ( J:88078 )

• hepatocellular carcinoma (HCC) observed in 63.6% of male mice and in 42.9% of female mice after 18 months of age

• no metastases were detected

• HCC was multifocal with most mice exhibiting1 to 2 highly vascularized large tumors (0.5 to 2.5 cm) and many smaller tumors distributed throughout

• HCC compressing adjacent normal hepatocytes observed after 18 months of age and typically associated with fatty liver and inflammation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:88078

Genotype
MGI:3046835

ht2

• Allelic Composition: Cdkn1a^tm2(HBx)Xya/Cdkn1a⁺
• Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss)

neoplasm

increased hepatocellular carcinoma incidence ( J:88078 )

• hepatocellular carcinoma observed in 60.0% of male mice and in 45.5% of female mice after 18 months of age

• no metastases were detected

• HCC was multifocal with most mice exhibiting1 to 2 highly vascularized large tumors (0.5 to 2.5 cm) and many smaller tumors distributed throughout

• HCC compressing adjacent normal hepatocytes observed after 18 months of age and typically associated with fatty liver and inflammation

liver/biliary system

hepatic steatosis ( J:88078 )

• observed in some mice

increased hepatocellular carcinoma incidence ( J:88078 )

• hepatocellular carcinoma observed in 60.0% of male mice and in 45.5% of female mice after 18 months of age

• no metastases were detected

• HCC was multifocal with most mice exhibiting1 to 2 highly vascularized large tumors (0.5 to 2.5 cm) and many smaller tumors distributed throughout

• HCC compressing adjacent normal hepatocytes observed after 18 months of age and typically associated with fatty liver and inflammation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:88078