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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Arr2/Pbsn-FGFR1K656E)1Wmck
transgene insertion 1, Wallace L McKeenan
MGI:3039371
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tg(Arr2/Pbsn-FGFR1K656E)1Wmck/0
Tg(Pbsn-FGFR2_iiib*)#Ng/0 		involves: FVB MGI:5566522
tg2
 		Tg(Arr2/Pbsn-FGFR1K656E)1Wmck/0 involves: FVB MGI:5565708


Genotype
MGI:5566522
cx1
Allelic
Composition		 Tg(Arr2/Pbsn-FGFR1K656E)1Wmck/0
Tg(Pbsn-FGFR2_iiib*)#Ng/0
Genetic
Background		 involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased prostate intraepithelial neoplasia incidence ( J:87067 )
• mice develop high-grade prostate intraepithelial neoplasia (PIN) foci after 6 months of age

reproductive system
increased prostate intraepithelial neoplasia incidence ( J:87067 )
• mice develop high-grade prostate intraepithelial neoplasia (PIN) foci after 6 months of age

endocrine/exocrine glands
increased prostate intraepithelial neoplasia incidence ( J:87067 )
• mice develop high-grade prostate intraepithelial neoplasia (PIN) foci after 6 months of age




Genotype
MGI:5565708
tg2
Allelic
Composition		 Tg(Arr2/Pbsn-FGFR1K656E)1Wmck/0
Genetic
Background		 involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased prostate intraepithelial neoplasia incidence ( J:87067 )
• mice develop high-grade prostate intraepithelial neoplasia (PIN) in every lobe of the prostate within 8 months
• the basement membrane is disrupted around the high-grade PIN
• neuroendocrine cell population is somewhat increased in prostates

reproductive system
increased prostate intraepithelial neoplasia incidence ( J:87067 )
• mice develop high-grade prostate intraepithelial neoplasia (PIN) in every lobe of the prostate within 8 months
• the basement membrane is disrupted around the high-grade PIN
• neuroendocrine cell population is somewhat increased in prostates

endocrine/exocrine glands
increased prostate intraepithelial neoplasia incidence ( J:87067 )
• mice develop high-grade prostate intraepithelial neoplasia (PIN) in every lobe of the prostate within 8 months
• the basement membrane is disrupted around the high-grade PIN
• neuroendocrine cell population is somewhat increased in prostates




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory