Phenotypes associated with this allele

• Allele Symbol: Ncapg2^tm1Jdc
• Allele Name: targeted mutation 1, John D Crispino
• Allele ID: MGI:3039486
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ncapg2^tm1Jdc/Ncapg2^tm1Jdc	involves: 129S1/Sv * C57BL/6	MGI:3039494

Genotype
MGI:3039494

hm1

• Allelic Composition: Ncapg2^tm1Jdc/Ncapg2^tm1Jdc
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:87685 )

• embryos die around E6 due to a failure of inner cell mass expansion, shortly after implantation and prior to gastrulation and blood cell development

embryo

abnormal inner cell mass apoptosis ( J:87685 )

• significantly higher number of TUNEL positive nuclei in the ICM

absent inner cell mass proliferation ( J:87685 )

• mutant blastocysts fail to exhibit outgrowth of the ICM, both in vitro and in vivo

absent egg cylinders ( J:87685 )

• embryos implant but do not undergo the proliferative burst that leads to formation of the egg cylinder

cellular

abnormal inner cell mass apoptosis ( J:87685 )

• significantly higher number of TUNEL positive nuclei in the ICM

absent inner cell mass proliferation ( J:87685 )

• mutant blastocysts fail to exhibit outgrowth of the ICM, both in vitro and in vivo