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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(HRAS)2Jic
transgene insertion 2, Central Institute for Experimental Animals, Japan
MGI:3039548
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Irf1tm1Mak/Irf1tm1Mak
Tg(HRAS)2Jic/?
involves: 129S2/SvPas * BALB/c * C57BL/6 MGI:4819237
cx2
Flt4tm1.1Ichi/Flt4+
Tg(HRAS)2Jic/0
involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2 MGI:4821322
cx3
Flt4tm1.1Ichi/Flt4+
Krastm1Mok/Kras+
Tg(HRAS)2Jic/0
involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2 MGI:4821326
cx4
Hrastm1Mok/Hrastm1Mok
Krastm1Mok/Kras+
Nrastm1Mok/Nras+
Tg(HRAS)2Jic/0
involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2 MGI:4821330
cx5
Hrastm1Mok/Hrastm1Mok
Nrastm1Mok/Nrastm1Mok
Tg(HRAS)2Jic/0
involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2 MGI:4821332
cx6
Krastm1Mok/Kras+
Nrastm1Mok/Nrastm1Mok
Tg(HRAS)2Jic/0
involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2 MGI:4821336
tg7
Tg(HRAS)2Jic/? involves: BALB/c * C57BL/6 MGI:4819236


Genotype
MGI:4819237
cx1
Allelic
Composition
Irf1tm1Mak/Irf1tm1Mak
Tg(HRAS)2Jic/?
Genetic
Background
involves: 129S2/SvPas * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf1tm1Mak mutation (1 available); any Irf1 mutation (21 available)
Tg(HRAS)2Jic mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• 44% develop tumors as compared to 7% of controls
• angiosarcomas observed most frequently




Genotype
MGI:4821322
cx2
Allelic
Composition
Flt4tm1.1Ichi/Flt4+
Tg(HRAS)2Jic/0
Genetic
Background
involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt4tm1.1Ichi mutation (0 available); any Flt4 mutation (77 available)
Tg(HRAS)2Jic mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
N
• no mice exhibit chylous ascites




Genotype
MGI:4821326
cx3
Allelic
Composition
Flt4tm1.1Ichi/Flt4+
Krastm1Mok/Kras+
Tg(HRAS)2Jic/0
Genetic
Background
involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt4tm1.1Ichi mutation (0 available); any Flt4 mutation (77 available)
Krastm1Mok mutation (6 available); any Kras mutation (84 available)
Tg(HRAS)2Jic mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• 1 of 13 mice develop chylous ascites unlike wild-type mice

immune system
• a few mice exhibit lymphatic vessel hypoplasia




Genotype
MGI:4821330
cx4
Allelic
Composition
Hrastm1Mok/Hrastm1Mok
Krastm1Mok/Kras+
Nrastm1Mok/Nras+
Tg(HRAS)2Jic/0
Genetic
Background
involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrastm1Mok mutation (15 available); any Hras mutation (30 available)
Krastm1Mok mutation (6 available); any Kras mutation (84 available)
Nrastm1Mok mutation (7 available); any Nras mutation (44 available)
Tg(HRAS)2Jic mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
N
• no mice exhibit chylous ascites




Genotype
MGI:4821332
cx5
Allelic
Composition
Hrastm1Mok/Hrastm1Mok
Nrastm1Mok/Nrastm1Mok
Tg(HRAS)2Jic/0
Genetic
Background
involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrastm1Mok mutation (15 available); any Hras mutation (30 available)
Nrastm1Mok mutation (7 available); any Nras mutation (44 available)
Tg(HRAS)2Jic mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
N
• no mice exhibit chylous ascites




Genotype
MGI:4821336
cx6
Allelic
Composition
Krastm1Mok/Kras+
Nrastm1Mok/Nrastm1Mok
Tg(HRAS)2Jic/0
Genetic
Background
involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm1Mok mutation (6 available); any Kras mutation (84 available)
Nrastm1Mok mutation (7 available); any Nras mutation (44 available)
Tg(HRAS)2Jic mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
N
• no mice exhibit chylous ascites




Genotype
MGI:4819236
tg7
Allelic
Composition
Tg(HRAS)2Jic/?
Genetic
Background
involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(HRAS)2Jic mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 77 week survival rate for males is 53% and for females is 32%

limbs/digits/tail
• skeletal myopathy in femoral muscle
• heart tongue and esophagus muscles are normal

growth/size/body
• body weights up to 36 weeks of age are between 80 and 100% of controls

neoplasm
N
• no tumors or pre-neoplasias among F2 mice within the first 6 months
• point mutations often found in transgene in cells from tumors
• 24/50 F2 mice develop tumors within 18 months
• 6/24 F2 mice that developed tumors developed double tumors
• N-methyl-N-nitrosourea (MNU) induced tumors involve point mutations in transgene while ENU induced tumors do not (J:73016)
• transgene overexpression in tumors induced by MNU, ENU, and urethane (J:73016)
• incidence of chemically induced lung adenomas and hyperplasia is higher than in controls (J:101590)
• chemical induction of papillomas and squamous cell carcinomas of the forestomach are common (J:101590)
• chemically induced hemangiosarcomas of the esophagus and small intestine are common (J:101590)
• one example within 3 months
• 3 skin papillomas in 50 F2 mice
• 2 lymphomas in 50 F2 mice
• 4 harderian gland adenocarcinomas in 50 F2 mice
• 8 lung adenocarcinomas in 50 F2 mice
• founder and 2 of 20 F1 mice develop angiosarcoma within 5 months
• 13 angiosarcomas in 50 F2 mice

respiratory system
• 8 lung adenocarcinomas in 50 F2 mice

muscle
• myopathic changes seen at 10-13 weeks in biceps femoris, gastrocnemius, and triceps brachii
• increased cell density occasionally
• diaphragm and soleus are normal
• skeletal myopathy in femoral muscle
• heart tongue and esophagus muscles are normal
• biceps femoris is most susceptible to myopathic changes
• internal architecture of muscle fibers becomes disorganized
• scattered (J:99371)
• some hyaline degeneration of muscle fibers observed (J:135606)
• some increase in interstitial collagen fibers

homeostasis/metabolism
• N-methyl-N-nitrosourea (MNU) induced tumors involve point mutations in transgene while ENU induced tumors do not (J:73016)
• transgene overexpression in tumors induced by MNU, ENU, and urethane (J:73016)
• incidence of chemically induced lung adenomas and hyperplasia is higher than in controls (J:101590)
• chemical induction of papillomas and squamous cell carcinomas of the forestomach are common (J:101590)
• chemically induced hemangiosarcomas of the esophagus and small intestine are common (J:101590)

integument
• one example within 3 months
• 3 skin papillomas in 50 F2 mice





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory