Phenotypes associated with this allele

• Allele Symbol: Tg(TacLIZa)A1Jsh
• Allele Name: transgene insertion A1, Jay M Short
• Allele ID: MGI:3039672
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Apex1^tm1Djc/Apex1^+ Tg(TacLIZa)A1Jsh/0	involves: 129X1/SvJ * C57BL/6 * NTac:NIHBS	MGI:3834457
cx2	Tg(EIF1AX-PMS2*)685Tcar/0 Tg(TacLIZa)A1Jsh/0	involves: C57BL/6 * SJL	MGI:4358136

Genotype
MGI:3834457

cx1

• Allelic Composition: Apex1^tm1Djc/Apex1⁺; Tg(TacLIZa)A1Jsh/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * NTac:NIHBS

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell physiology ( J:92957 )

• spontaneous mutation frequency for mixed spermatogenic cells

abnormal DNA repair ( J:92957 )

• spontaneous mutation frequency for mixed spermatogenic cells from 9-month-old double mutant mice is 2-fold higher than for wild-type Apex1 hemizygous Tg mice

• spontaneous mutation frequency observed in liver samples in 3-month-old animals is significantly higher compared to age matched wild-type Apex1 hemizygous Tg mice; a further 1.5-fold increase is observed in samples from 9-month-old animals

• spontaneous mutation frequency observed in liver samples in 9-month-old animals is significantly higher compared to 3-month-old mice of the same genotype, suggesting an age-related increase in frequency

• spontaneous mutation frequency observed in spleen samples from 3-month-old mice is 2-fold higher than in controls and an additional 2-fold increase is found in samples from 9-month-old mice

homeostasis/metabolism

abnormal DNA repair ( J:92957 )

• spontaneous mutation frequency for mixed spermatogenic cells from 9-month-old double mutant mice is 2-fold higher than for wild-type Apex1 hemizygous Tg mice

• spontaneous mutation frequency observed in liver samples in 3-month-old animals is significantly higher compared to age matched wild-type Apex1 hemizygous Tg mice; a further 1.5-fold increase is observed in samples from 9-month-old animals

• spontaneous mutation frequency observed in liver samples in 9-month-old animals is significantly higher compared to 3-month-old mice of the same genotype, suggesting an age-related increase in frequency

• spontaneous mutation frequency observed in spleen samples from 3-month-old mice is 2-fold higher than in controls and an additional 2-fold increase is found in samples from 9-month-old mice

Genotype
MGI:4358136

cx2

• Allelic Composition: Tg(EIF1AX-PMS2*)685Tcar/0; Tg(TacLIZa)A1Jsh/0
• Genetic Background: involves: C57BL/6 * SJL

cellular

abnormal cell physiology ( J:152364 )

abnormal DNA repair ( J:152364 )

• in mice expressing only the Tg(TacLIZa)A1Jsh (Big Blue^TM transgene), the normal background mutation frequency was determined to be 1.62E-05 using DNA from liver, whereas tissue from double transgenic mice (expressing the Big Blue^TM reporter transgene and Tg(EIF1AX-PMS2*)685Tcar (Mophogene^TM)) displayed a mutation frequency of 4.0E-05 (2.5-fold higher than wild-type)

homeostasis/metabolism

abnormal DNA repair ( J:152364 )

• in mice expressing only the Tg(TacLIZa)A1Jsh (Big Blue^TM transgene), the normal background mutation frequency was determined to be 1.62E-05 using DNA from liver, whereas tissue from double transgenic mice (expressing the Big Blue^TM reporter transgene and Tg(EIF1AX-PMS2*)685Tcar (Mophogene^TM)) displayed a mutation frequency of 4.0E-05 (2.5-fold higher than wild-type)