Phenotypes associated with this allele

• Allele Symbol: Tg(IghMyc)186Brn
• Allele Name: transgene insertion 186, Anton Berns
• Allele ID: MGI:3039690
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(IghMyc)186Brn/0 Rpl24^Bst/Rpl24^+	involves: C57BL/LiA * C57BLKS * CBA/BrA	MGI:3831134
cx2	Tg(IghMyc)186Brn/0 Rpl38^tm1Rugg/Rpl38^+	involves: C57BL/LiA * CBA/BrA	MGI:3831135
tg3	Tg(IghMyc)186Brn/0	involves: C57BL/LiA * CBA/BrA	MGI:3831133

Genotype
MGI:3831134

cx1

• Allelic Composition: Tg(IghMyc)186Brn/0; Rpl24^Bst/Rpl24⁺
• Genetic Background: involves: C57BL/LiA * C57BLKS * CBA/BrA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

cellular phenotype ( J:142390 )

N • number of S phase lymphocytes is more normal

N • lymphocytes with duplicated centrosomes are eliminated or reduced in number

increased apoptosis ( J:142390 )

• double the number of apoptotic lymphocytes as compared to mice with Tg(IghMyc)186Brn alone

immune system

immune system phenotype ( J:142390 )

N • splenomegaly is reduced

neoplasm

neoplasm ( J:142390 )

N • onset of lymphomas is delayed and many mice never develop lymphomas

Genotype
MGI:3831135

cx2

• Allelic Composition: Tg(IghMyc)186Brn/0; Rpl38^tm1Rugg/Rpl38⁺
• Genetic Background: involves: C57BL/LiA * CBA/BrA

cellular

cellular phenotype ( J:142390 )

N • number of S phase lymphocytes is more normal

increased apoptosis ( J:142390 )

• increased cell death in precancerous cells

neoplasm

neoplasm ( J:142390 )

N • marked suppression of lymphoma formation

Genotype
MGI:3831133

tg3

• Allelic Composition: Tg(IghMyc)186Brn/0
• Genetic Background: involves: C57BL/LiA * CBA/BrA

cellular

abnormal intracellular organelle morphology ( J:142390 )

• large percentage of lymphocytes have duplicated centrosomes

binucleate ( J:142390 )

• increased number of binucleated lymphocytes

abnormal cell cycle ( J:142390 )

• increased number of B cells in S phase

• defects in cytokinesis

abnormal mitosis ( J:142390 )

• increased protein synthesis during mitosis