All Phenotypes Tg(Tyr-rtTA)37Lc MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Tg(tetO-Nras*Q61K)#Lc/0 Tg(Tyr-rtTA)37Lc/0	FVB.Cg-Cdkn2a^tm1Rdp Tg(tetO-Nras*Q61K)#Lc Tg(Tyr-rtTA)37Lc	MGI:5818051
cx2	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Tg(tetO-BRAF*V600E)29Lc/0 Tg(Tyr-rtTA)37Lc/0	involves: 129/Sv * C57BL/6J * SJL	MGI:3834745
cx3	A^y/a Tg(tetO-Ppargc1a)1Dpk/0 Tg(Tyr-rtTA)37Lc/0	involves: FVB	MGI:6259414

Allelic Composition	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Tg(tetO-Nras*Q61K)#Lc/0 Tg(Tyr-rtTA)37Lc/0
Genetic Background	FVB.Cg-Cdkn2a^tm1Rdp Tg(tetO-Nras*Q61K)#Lc Tg(Tyr-rtTA)37Lc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm1Rdp mutation (6 available); any Cdkn2a mutation (67 available)
Tg(tetO-Nras*Q61K)#Lc mutation (0 available)
Tg(Tyr-rtTA)37Lc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

increased cutaneous melanoma incidence ( J:238049 )

• mice administered doxycycline at weaning develop spontaneous melanoma after an average of 15 weeks with a 50% penetrance

• withdrawal of doxycycline results in rapid, durable and complete tumor regression within 10 days

• doxycycline treated mice administered the MEK inhibitor Selumetinib or GSK1120212 show tumor stasis but not tumor regression

• doxycycline treated mice administered a selective inhibitor of CDK4/6, PD-0332991 together with either Selumetinib or GSK1120212 show tumor regression

neoplasm

increased cutaneous melanoma incidence ( J:238049 )

• mice administered doxycycline at weaning develop spontaneous melanoma after an average of 15 weeks with a 50% penetrance

• withdrawal of doxycycline results in rapid, durable and complete tumor regression within 10 days

• doxycycline treated mice administered the MEK inhibitor Selumetinib or GSK1120212 show tumor stasis but not tumor regression

• doxycycline treated mice administered a selective inhibitor of CDK4/6, PD-0332991 together with either Selumetinib or GSK1120212 show tumor regression

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:144358 )

• 50% of doxycycline-treated mice die due to generally compromised physiological state secondary to renal failure despite frequent bladder irrigations

neoplasm

increased prostate gland adenocarcinoma incidence ( J:144358 )

• at 24 weeks after doxycycline induction, mice develop prostate adenocarcinomas that exhibit epithelial-mesenchyme transition

• doxycycline-induced prostate adenomas can compress the bladder, originate from epithelial cells and express luminal, intermediate and basal cell markers

• doxycycline-treated mice that are subsequently castrated exhibit reduced prostate tumor proliferation compared to pre-castration

• withdrawal of doxycycline does not affect tumor cell proliferation

endocrine/exocrine glands

prostate gland hyperplasia ( J:144358 )

• at 16 weeks after doxycycline induction, prostates exhibit basaloid hyperplasia driven by urogenital epithelium unlike in wild-type mice

increased prostate gland adenocarcinoma incidence ( J:144358 )

• at 24 weeks after doxycycline induction, mice develop prostate adenocarcinomas that exhibit epithelial-mesenchyme transition

• doxycycline-induced prostate adenomas can compress the bladder, originate from epithelial cells and express luminal, intermediate and basal cell markers

• doxycycline-treated mice that are subsequently castrated exhibit reduced prostate tumor proliferation compared to pre-castration

• withdrawal of doxycycline does not affect tumor cell proliferation

abnormal prostate gland physiology ( J:144358 )

• at 5 weeks after doxycycline induction, prostates exhibit a moderate degree of aberrant proliferation unlike in wild-type mice

reproductive system

prostate gland hyperplasia ( J:144358 )

• at 16 weeks after doxycycline induction, prostates exhibit basaloid hyperplasia driven by urogenital epithelium unlike in wild-type mice

increased prostate gland adenocarcinoma incidence ( J:144358 )

• at 24 weeks after doxycycline induction, mice develop prostate adenocarcinomas that exhibit epithelial-mesenchyme transition

• doxycycline-induced prostate adenomas can compress the bladder, originate from epithelial cells and express luminal, intermediate and basal cell markers

• doxycycline-treated mice that are subsequently castrated exhibit reduced prostate tumor proliferation compared to pre-castration

• withdrawal of doxycycline does not affect tumor cell proliferation

abnormal prostate gland physiology ( J:144358 )

• at 5 weeks after doxycycline induction, prostates exhibit a moderate degree of aberrant proliferation unlike in wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:144358

Allelic Composition	A^y/a Tg(tetO-Ppargc1a)1Dpk/0 Tg(Tyr-rtTA)37Lc/0
Genetic Background	involves: FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A^y mutation (12 available); any a mutation (463 available)
Tg(tetO-Ppargc1a)1Dpk mutation (1 available)
Tg(Tyr-rtTA)37Lc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

darkened coat color ( J:194191 )

• upon induction of Ppargc1a expression in melanocytes, mice exhibit a noticeably darkened coat color relative to the yellow coat color of A^y/a Tg(Tyr-rtTA)37Lc/0 mice; however, the coat color does not become completely black

abnormal hair follicle melanogenesis ( J:194191 )

• upon induction of Ppargc1a expression in melanocytes, mice exhibit significantly increased presence of melanin in hair follicles relative to A^y/a Tg(Tyr-rtTA)37Lc/0 mice

integument

darkened coat color ( J:194191 )

abnormal hair follicle melanogenesis ( J:194191 )

• upon induction of Ppargc1a expression in melanocytes, mice exhibit significantly increased presence of melanin in hair follicles relative to A^y/a Tg(Tyr-rtTA)37Lc/0 mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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