Phenotypes associated with this allele

• Allele Symbol: Prm1^tm1Eddy
• Allele Name: targeted mutation 1, Edward M Eddy
• Allele ID: MGI:3039794
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Prm1^tm1Eddy/Prm1^+	either: (chimera involves: 129P2/OlaHsd * C57BL/6N) or (chimera involves: 129S1/Sv * 129X1/SvJ * C57BL/6N)	MGI:3039826

Genotype
MGI:3039826

ht1

• Allelic Composition: Prm1^tm1Eddy/Prm1⁺
• Genetic Background: either: (chimera involves: 129P2/OlaHsd * C57BL/6N) or (chimera involves: 129S1/Sv * 129X1/SvJ * C57BL/6N)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

teratozoospermia ( J:69127 )

♂ • sperm are found with the flagellum attached to the head and with heads narrowed and reduced in curvature

♂ • chimeras with a greater percentage of 129 sperm also have a greater percentage of deformed sperm

♂ • DNA in 129 sperm is not as compacted and released more readily than in B6 sperm

immotile sperm ( J:69127 )

♂ • 129 sperm from chimeras is immotile

reproductive system

teratozoospermia ( J:69127 )

♂ • sperm are found with the flagellum attached to the head and with heads narrowed and reduced in curvature

♂ • chimeras with a greater percentage of 129 sperm also have a greater percentage of deformed sperm

♂ • DNA in 129 sperm is not as compacted and released more readily than in B6 sperm

immotile sperm ( J:69127 )

♂ • 129 sperm from chimeras is immotile

infertility ( J:69127 )

• both male and female chimeras produce only non-agouti (B6) offspring

abnormal fertilization ( J:69127 )

• sperm derived from spermatogenic cells with one copy of the mutated allele are unable to fertilize eggs