Phenotypes associated with this allele

• Allele Symbol: Itpkb^T-less
• Allele Name: Ms. T-less
• Allele ID: MGI:3039799
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Itpkb^T-less/Itpkb^T-less	C57BL/6-Itpkb^T-less	MGI:3040623

Genotype
MGI:3040623

hm1

• Allelic Composition: Itpkb^T-less/Itpkb^T-less
• Genetic Background: C57BL/6-Itpkb^T-less

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

arrested T cell differentiation ( J:89286 )

• complete block of thymocyte development at the CD4⁺CD8⁺ stage

• bone marrow reconstitution experiments indicated that the block in T cell maturation is T cell intrinsic and not dependent pn ligands on, or signals from, the thymic epithelium

abnormal T cell physiology ( J:89286 )

• attenuated extracellular signal-regulated kinase (ERK) activation in response to suboptimal antigen receptor stimulation

• normal Ca²⁺ signaling responses in thymocytes

immune system

arrested T cell differentiation ( J:89286 )

• complete block of thymocyte development at the CD4⁺CD8⁺ stage

• bone marrow reconstitution experiments indicated that the block in T cell maturation is T cell intrinsic and not dependent pn ligands on, or signals from, the thymic epithelium

abnormal T cell physiology ( J:89286 )

• attenuated extracellular signal-regulated kinase (ERK) activation in response to suboptimal antigen receptor stimulation

• normal Ca²⁺ signaling responses in thymocytes