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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Stat3tm2Vpo
targeted mutation 2, Valeria Poli
MGI:3040152
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Stat3tm2Vpo/Stat3tm2Vpo involves: C57BL/6 * CBA * BALB/cAn MGI:3040649
cn2
 		Stat3tm1Vpo/Stat3tm2Vpo
Tg(Mx1-cre)1Cgn/0 		involves: C57BL/6 * CBA * BALB/cAn MGI:3040651


Genotype
MGI:3040649
hm1
Allelic
Composition		 Stat3tm2Vpo/Stat3tm2Vpo
Genetic
Background		 involves: C57BL/6 * CBA * BALB/cAn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3tm2Vpo mutation (0 available); any Stat3 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, complete penetrance ( J:89194 )
• mice developed breathing difficulties, became cyanotic, and died within 16 hours of birth




Genotype
MGI:3040651
cn2
Allelic
Composition		 Stat3tm1Vpo/Stat3tm2Vpo
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: C57BL/6 * CBA * BALB/cAn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3tm1Vpo mutation (0 available); any Stat3 mutation (72 available)
Stat3tm2Vpo mutation (0 available); any Stat3 mutation (72 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:89194 )
• increased TNF and IL-6 production by peritoneal macrophages stimulated by LPS and IFN-gamma, relative to those of wild-type
increased interleukin-6 secretion ( J:89194 )
• increased IL-6 production by peritoneal macrophages stimulated by LPS and IFN-gamma, relative to those of wild-type
increased tumor necrosis factor secretion ( J:89194 )
• increased TNF production by peritoneal macrophages stimulated by LPS and IFN-gamma, relative to those of wild-type

hematopoietic system
abnormal macrophage physiology ( J:89194 )
• increased TNF and IL-6 production by peritoneal macrophages stimulated by LPS and IFN-gamma, relative to those of wild-type




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory