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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Stat3tm3Vpo
targeted mutation 3, Valeria Poli
MGI:3040161
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Stat3tm3Vpo/Stat3tm3Vpo involves: C57BL/6 * CBA * BALB/cAn MGI:3040650


Genotype
MGI:3040650
hm1
Allelic
Composition		 Stat3tm3Vpo/Stat3tm3Vpo
Genetic
Background		 involves: C57BL/6 * CBA * BALB/cAn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3tm3Vpo mutation (0 available); any Stat3 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:89194 )
• increased TNF and IL-6 production by peritoneal macrophages stimulated by LPS and IFN-gamma, relative to those of wild-type

hematopoietic system
abnormal macrophage physiology ( J:89194 )
• increased TNF and IL-6 production by peritoneal macrophages stimulated by LPS and IFN-gamma, relative to those of wild-type




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory