Phenotypes associated with this allele

• Allele Symbol: Mapk7^tm1Jdl
• Allele Name: targeted mutation 1, Jiing-Dwan Lee
• Allele ID: MGI:3040180
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mapk7^tm1Jdl/Mapk7^tm1Jdl	Not Specified	MGI:3042040
cn2	Mapk7^tm1Jdl/Mapk7^tm1Jdl Tg(Mx1-cre)1Cgn/0	involves: C57BL/6 * CBA	MGI:3042041
cn3	Mapk7^tm1Jdl/Mapk7^tm1Jdl Tg(Tek-cre)12Flv/0	Not Specified	MGI:3042042
cn4	Mapk7^tm1Jdl/Mapk7^tm1Jdl Tg(Myhca-cre)1Abel/0	Not Specified	MGI:3042043

Genotype
MGI:3042040

hm1

• Allelic Composition: Mapk7^tm1Jdl/Mapk7^tm1Jdl
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:89215 )

• mice were healthy and fertile

Genotype
MGI:3042041

cn2

• Allelic Composition: Mapk7^tm1Jdl/Mapk7^tm1Jdl; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: C57BL/6 * CBA

mortality/aging

premature death ( J:89215 )

• adult mice developed a wasting syndrome and died 2 to 4 weeks after induction of cre recombinase

behavior/neurological

head tilt ( J:89215 )

• approximately 30% displayed head tilting and hemiparesis

cardiovascular system

abnormal blood vessel morphology ( J:89215 )

• the endothelial cells lining the blood vessels became round, irregularly aligned, and apoptotic

abnormal heart morphology ( J:89215 )

• multifocal cellular plaques containing large round cells observed in the ventricle

myocardial fiber degeneration ( J:89215 )

• diffused degeneration of myocardial fibers was observed along with multifocal inflammatory changes

hemorrhage ( J:89215 )

• multifocal acute hemorrhages in multiple organs including the heart, brain, and lung

• associated with abnormal endothelial cells

abnormal vascular permeability ( J:89215 )

• blood vessels became abnormally leaky

cellular

abnormal apoptosis ( J:89215 )

• apoptosis of endothelial cells leading to increased vascular permeability and hemorrage

growth/size/body

cachexia ( J:89215 )

muscle

myocardial fiber degeneration ( J:89215 )

• diffused degeneration of myocardial fibers was observed along with multifocal inflammatory changes

Genotype
MGI:3042042

cn3

• Allelic Composition: Mapk7^tm1Jdl/Mapk7^tm1Jdl; Tg(Tek-cre)12Flv/0
• Genetic Background: Not Specified

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:89215 )

• fetuses died between E9.5 and E10.5 exhibiting cardiovascular defects

cardiovascular system

abnormal vitelline vasculature morphology ( J:89215 )

• abnormal yolk sac blood vessels, appearing loose and fragile

trabecula carnea hypoplasia ( J:89215 )

• reduced trabeculation in the ventricular chamber

abnormal heart development ( J:89215 )

• impaired myocardium development when compared to controls

abnormal endocardium morphology ( J:89215 )

• impaired endocardium development with the abnormally shaped endothelial cells irregularly aligning with the myocardium

embryo

abnormal vitelline vasculature morphology ( J:89215 )

• abnormal yolk sac blood vessels, appearing loose and fragile

muscle

trabecula carnea hypoplasia ( J:89215 )

• reduced trabeculation in the ventricular chamber

Genotype
MGI:3042043

cn4

• Allelic Composition: Mapk7^tm1Jdl/Mapk7^tm1Jdl; Tg(Myhca-cre)1Abel/0
• Genetic Background: Not Specified

normal phenotype

no abnormal phenotype detected ( J:89215 )

• mice were viable and showed no overt defects through 1 year of age