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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(rTH-Tag)20Dmc
transgene insertion 20, Dona M Chikaraishi
MGI:3040267
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(rTH-Tag)20Dmc/0 involves: C57BL/6NTac * DBA/2NTac MGI:5442286


Genotype
MGI:5442286
tg1
Allelic
Composition
Tg(rTH-Tag)20Dmc/0
Genetic
Background
involves: C57BL/6NTac * DBA/2NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• adrenal glands develop tumors resembling neuroblastomas
• both adrenal and brain tumors resemble neuroblastomas composed of small, densely packed, undifferentiated cells with scant cytoplasm
• no other organ besides the brain and adrenal glands develop a tumor
• mutants develop brain tumors, with onset of tumors varying from 15 weeks to 8.5 months
• tumors are found on the ventral aspect of the brain, centered about the midbrain and rostral brainstem
• tumor bearing mutants exhibit motor difficulties, a hunched posture, and enlarged head

nervous system
• both adrenal and brain tumors resemble neuroblastomas composed of small, densely packed, undifferentiated cells with scant cytoplasm
• no other organ besides the brain and adrenal glands develop a tumor
• mutants develop brain tumors, with onset of tumors varying from 15 weeks to 8.5 months
• tumors are found on the ventral aspect of the brain, centered about the midbrain and rostral brainstem
• tumor bearing mutants exhibit motor difficulties, a hunched posture, and enlarged head

endocrine/exocrine glands
• adrenal glands develop tumors resembling neuroblastomas

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
neuroblastoma DOID:769 J:90323





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory