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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		L1camtm1.1Vlem
targeted mutation 1.1 Vance Lemmon
MGI:3040294
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		L1camtm1.1Vlem/L1camtm1.1Vlem 129S2.Cg-L1camtm1.1Vlem MGI:3041396
hm2
 		L1camtm1.1Vlem/L1camtm1.1Vlem B6.Cg-L1camtm1.1Vlem MGI:3041398


Genotype
MGI:3041396
hm1
Allelic
Composition		 L1camtm1.1Vlem/L1camtm1.1Vlem
Genetic
Background		 129S2.Cg-L1camtm1.1Vlem
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
L1camtm1.1Vlem mutation (0 available); any L1cam mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:89300 )
• on a 129/Sv genetic background, a slightly lower percentage of mutant males were born

nervous system
nervous system phenotype ( J:89300 )
N
• no hydroencephaly or other morphological abnormalities of the brain or spinal cord were observed on a 129/Sv genetic background




Genotype
MGI:3041398
hm2
Allelic
Composition		 L1camtm1.1Vlem/L1camtm1.1Vlem
Genetic
Background		 B6.Cg-L1camtm1.1Vlem
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
L1camtm1.1Vlem mutation (0 available); any L1cam mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:89300 )
• Background Sensitivity: mice on a C57BL/6 genetic background that survived birth, died prior to P6
prenatal lethality, incomplete penetrance ( J:89300 )
• Background Sensitivity: mice that had been backcrossed to the C57BL/6 genetic background for 5 to 9 generations showed increased embryonic lethality with only a small percentage of such mice surviving birth

nervous system
hydrocephaly ( J:89300 )
• Background Sensitivity: severe hyrdroencephaly observed in mice on a C57BL/6 genetic background, but not in mice on a 129/Sv genetic background




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory