All Phenotypes Tg(MMTVTGFB1)46Hlm MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Rb1^tm1Fad/Rb1^tm1Fad Tg(MMTVTGFB1)46Hlm/?	involves: 129 * C57BL/6 * DBA/2	MGI:4354285
cx2	Tg(MMTVTGFA)29Rjc/0 Tg(MMTVTGFB1)46Hlm/0	involves: C57BL/6 * DBA/2	MGI:3800247
tg3	Tg(MMTVTGFB1)46Hlm/0	involves: C57BL/6 * DBA/2	MGI:3800230

Allelic Composition	Rb1^tm1Fad/Rb1^tm1Fad Tg(MMTVTGFB1)46Hlm/?
Genetic Background	involves: 129 * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1^tm1Fad mutation (1 available); any Rb1 mutation (111 available)
Tg(MMTVTGFB1)46Hlm mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

mammary gland hyperplasia ( J:151417 )

• mammary glands have hyperplastic growth throughout development

• hyperplasia was characterized by increased luminal epithelial cell layers, as well as invagination of the epithelium into the lumen of the duct

• this genotype demonstrates that mammary hyperplasia associated with Rb1^tm1Fad homozygotes still occurs in the presence of high levels of TGF-beta1

integument

mammary gland hyperplasia ( J:151417 )

• mammary glands have hyperplastic growth throughout development

• hyperplasia was characterized by increased luminal epithelial cell layers, as well as invagination of the epithelium into the lumen of the duct

• this genotype demonstrates that mammary hyperplasia associated with Rb1^tm1Fad homozygotes still occurs in the presence of high levels of TGF-beta1

Allelic Composition	Tg(MMTVTGFA)29Rjc/0 Tg(MMTVTGFB1)46Hlm/0
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MMTVTGFA)29Rjc mutation (1 available)
Tg(MMTVTGFB1)46Hlm mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

mammary gland alveolar hyperplasia ( J:71696 )

• widely scattered hyperplastic alveolar outgrowths are present

neoplasm

neoplasm ( J:71696 )

N	• unlike mice overexpressing TGFA, mice do not exhibit mammary tumors

integument

mammary gland alveolar hyperplasia ( J:71696 )

• widely scattered hyperplastic alveolar outgrowths are present

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:72128 )

N	• despite abnormal morphology, mice are still able to produce milk and normally nurse their young

abnormal mammary gland morphology ( J:72128 )

abnormal branching of the mammary ductal tree ( J:71696 , J:72128 )

• multiparous mice exhibit reduced ductal branching compared to wild-type mice (J:71696)

• mammary duct tree branching development is suppressed due to decreased proliferation of mammary epithelial cells (J:72128)

• at week 13, lateral branching is virtually absent (J:72128)

abnormal mammary gland luminal epithelium morphology ( J:72128 )

• during lactation ductal and alveolar epithelial cells appear more flattened and somewhat atrophic compared to in wild-type mice

abnormal mammary gland lobule morphology ( J:72128 )

• pregnant and lactating glands exhibit fewer lobules than in wild-type mice

neoplasm

neoplasm ( J:72128 )

N	• unlike with overexpression of TGFA, mice do not exhibit mammary tumors

decreased incidence of tumors by chemical induction ( J:71696 )

• mice exhibit fewer DMBA-induced tumors than similarly treated wild-type mice

integument

abnormal mammary gland morphology ( J:72128 )

abnormal branching of the mammary ductal tree ( J:71696 , J:72128 )

• multiparous mice exhibit reduced ductal branching compared to wild-type mice (J:71696)

• mammary duct tree branching development is suppressed due to decreased proliferation of mammary epithelial cells (J:72128)

• at week 13, lateral branching is virtually absent (J:72128)

abnormal mammary gland luminal epithelium morphology ( J:72128 )

• during lactation ductal and alveolar epithelial cells appear more flattened and somewhat atrophic compared to in wild-type mice

abnormal mammary gland lobule morphology ( J:72128 )

• pregnant and lactating glands exhibit fewer lobules than in wild-type mice

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:71696 )

• mice exhibit fewer DMBA-induced tumors than similarly treated wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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