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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Epha2tm1Jrui
targeted mutation 1, Joseph C Ruiz
MGI:3040415
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Epha2tm1Jrui/Epha2tm1Jrui involves: 129 * BALB/c * C57BL/6 MGI:3041778
cn2
 		Epha2tm1Jrui/Epha2tm1Jrui
Krastm4Tyj/Kras+
Trp53tm2.1Tyj/Trp53+
Tg(Pdx1-cre)6Tuv/0 		involves: 129S/SvEv * 129S4/SvJae * FVB/N MGI:6113916


Genotype
MGI:3041778
hm1
Allelic
Composition		 Epha2tm1Jrui/Epha2tm1Jrui
Genetic
Background		 involves: 129 * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epha2tm1Jrui mutation (2 available); any Epha2 mutation (96 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal angiogenesis ( J:89275 )
• endothelial cells fail to assemble into capillary-like structure (vascular assembly) and to migrate in response to ephrin A1 (Efna1) in vitro
• mutants show impaired ephrin A1-induced angiogenesis in vivo




Genotype
MGI:6113916
cn2
Allelic
Composition		 Epha2tm1Jrui/Epha2tm1Jrui
Krastm4Tyj/Kras+
Trp53tm2.1Tyj/Trp53+
Tg(Pdx1-cre)6Tuv/0
Genetic
Background		 involves: 129S/SvEv * 129S4/SvJae * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epha2tm1Jrui mutation (2 available); any Epha2 mutation (96 available)
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
Trp53tm2.1Tyj mutation (2 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:244261 )
N
• phenotypes are relative to the control KPC (KrasG12D/+, p53R172H/+, Pdx1-Cre) PDAC (pancreatic adenocarcinoma) model mice
• size of PDAC primary tumors same as control
decreased metastatic potential ( J:244261 )
• significantly reduced number of detectable PDAC metastases to liver, lung and other tissues
• reduced migration of PDAC cells in vitro

mortality/aging
abnormal survival ( J:244261 )
• survival reduced compared to control




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory