About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pomctm1Sora
targeted mutation 1, S O'Rahilly
MGI:3040514
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pomctm1Sora/Pomctm1Sora involves: 129S2/SvHsd * 129S6/SvEvTac MGI:3041643
ht2
 		Pomctm1Sora/Pomc+ involves: 129S2/SvHsd * 129S6/SvEvTac MGI:3041651
cx3
 		a/A
Pomctm1Sora/Pomctm1Sora 		involves: 129S6/SvEvTac MGI:3805940
cx4
 		a/A
Mc1re/Mc1re
Pomctm1Sora/Pomctm1Sora
Tg(MC1R)1Jkn/? 		involves: 129S6/SvEvTac * C57BL/6Ha MGI:3805942
cx5
 		a/a
Mc1re/Mc1re
Pomctm1Sora/Pomctm1Sora
Tg(MC1R)1Jkn/? 		involves: 129S6/SvEvTac * C57BL/6Ha MGI:3805943


Genotype
MGI:3041643
hm1
Allelic
Composition		 Pomctm1Sora/Pomctm1Sora
Genetic
Background		 involves: 129S2/SvHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pomctm1Sora mutation (0 available); any Pomc mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
diluted coat color ( J:89244 )
• lighter ventral coat color than that of wild-type

behavior/neurological

growth/size/body
obese ( J:89244 )
• increased body weight, relative to controls, when on standard lab diet (4.5% fat)
• significantly higher fat and lean tissue mass relative to controls
• responses to both acute anoretic and chronic administration of peptide-YY3-36 were similar to those of wild-type
increased susceptibility to diet-induced obesity ( J:89244 )
• a high fat diet augmented the obese phenotype

homeostasis/metabolism
increased susceptibility to diet-induced obesity ( J:89244 )
• a high fat diet augmented the obese phenotype
decreased circulating corticosterone level ( J:89244 )
• corticosterone was undetectable
decreased oxygen consumption ( J:89244 )
• while oxygen consumption was increased in absolute terms, when corrected for total body mass, resting oxygen consumption was reduced relative to controls
decreased response to leptin ( J:89244 )
• attenuated affect on both food intake and weight loss in response to leptin; observed in older, obese, mice but not in younger, nonobese mice

integument
diluted coat color ( J:89244 )
• lighter ventral coat color than that of wild-type

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
obesity DOID:9970 OMIM:601665
 J:89244




Genotype
MGI:3041651
ht2
Allelic
Composition		 Pomctm1Sora/Pomc+
Genetic
Background		 involves: 129S2/SvHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pomctm1Sora mutation (0 available); any Pomc mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
diluted coat color ( J:89244 )
• lighter ventral coat color than that of wild-type

homeostasis/metabolism
decreased circulating corticosterone level ( J:89244 )
• decreased, in spite of normal adrenal gland structure

growth/size/body
increased susceptibility to diet-induced obesity ( J:89244 )

integument
integument phenotype ( J:89244 )
N
• normal pigmentation
diluted coat color ( J:89244 )
• lighter ventral coat color than that of wild-type




Genotype
MGI:3805940
cx3
Allelic
Composition		 a/A
Pomctm1Sora/Pomctm1Sora
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A mutation (19 available); any a mutation (463 available)
Pomctm1Sora mutation (0 available); any Pomc mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
yellow coat color ( J:129904 )
• mice have a slightly more yellow coat than agouti controls
abnormal hair follicle pheomelanosome pheomelanin content ( J:129904 )
• the phaeomelanin to total melanin ratio is higher (0.30) than in agouti controls (0.19)

integument
yellow coat color ( J:129904 )
• mice have a slightly more yellow coat than agouti controls
abnormal hair follicle pheomelanosome pheomelanin content ( J:129904 )
• the phaeomelanin to total melanin ratio is higher (0.30) than in agouti controls (0.19)




Genotype
MGI:3805942
cx4
Allelic
Composition		 a/A
Mc1re/Mc1re
Pomctm1Sora/Pomctm1Sora
Tg(MC1R)1Jkn/?
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6Ha
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A mutation (19 available); any a mutation (463 available)
Mc1re mutation (4 available); any Mc1r mutation (44 available)
Pomctm1Sora mutation (0 available); any Pomc mutation (21 available)
Tg(MC1R)1Jkn mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
yellow coat color ( J:129904 )
• mice have a much more yellow coat than agouti controls
abnormal hair follicle pheomelanosome pheomelanin content ( J:129904 )
• the phaeomelanin to total melanin ratio is higher (2.00) than in agouti controls (0.19)

integument
yellow coat color ( J:129904 )
• mice have a much more yellow coat than agouti controls
abnormal hair follicle pheomelanosome pheomelanin content ( J:129904 )
• the phaeomelanin to total melanin ratio is higher (2.00) than in agouti controls (0.19)




Genotype
MGI:3805943
cx5
Allelic
Composition		 a/a
Mc1re/Mc1re
Pomctm1Sora/Pomctm1Sora
Tg(MC1R)1Jkn/?
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6Ha
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
Mc1re mutation (4 available); any Mc1r mutation (44 available)
Pomctm1Sora mutation (0 available); any Pomc mutation (21 available)
Tg(MC1R)1Jkn mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
yellow coat color ( J:129904 )
• mice have a much more yellow coat than agouti controls
abnormal hair follicle pheomelanosome pheomelanin content ( J:129904 )
• the phaeomelanin to total melanin ratio is higher (1.74) than in controls (0.20)

integument
yellow coat color ( J:129904 )
• mice have a much more yellow coat than agouti controls
abnormal hair follicle pheomelanosome pheomelanin content ( J:129904 )
• the phaeomelanin to total melanin ratio is higher (1.74) than in controls (0.20)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory