Analysis Tools|
Allele Symbol Allele Name Allele ID |
Kcne1tm1Rdn targeted mutation 1, Dan M Roden MGI:3040614 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• I-Kr, the rapidly activating component of cardiac delayed rectifier current, is significantly reduced and its deactivation slowed in myocytes relative to controls, however QT interval is normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• I-Kr, the rapidly activating component of cardiac delayed rectifier current, is significantly reduced and its deactivation slowed in myocytes relative to controls
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|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice show disorganization of the proximal bundle of His
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• the atrioventricular node is more disorganized and fibrosis and large vacuoles are seen in the atrioventricular region
• hearts exhibit fewer conduction cells
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• mice show disorganization of the proximal bundle of His
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• the atrioventricular node is more disorganized and fibrosis and large vacuoles are seen in the atrioventricular region
• hearts exhibit fewer conduction cells
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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