Analysis Tools
endocrine/exocrine glands
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• the majority of ovaries in 8 month old mice appeared hemorrhagic
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• ovaries were histologically normal through 21 days of age
• defects became apparent after 3 months of age
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• some mice developed Sertoli cell tubule-like structures, reminiscent of the ovarian tumors observed in mice inhibin-deficient mice, mice overexpressing follistatin and follicle stimulating hormone, mice lacking both estrogen receptors alpha and beta, and mice overexpressing anti-Mullerian hormone
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• decreased numbers of antral follicles
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ovary cyst
(
J:89081
)
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• observed in 2 mice
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growth/size/body
ovary cyst
(
J:89081
)
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• observed in 2 mice
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homeostasis/metabolism
| N |
• circulating estradiol levels did not differ from those of controls
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reproductive system
| N |
• male mice were fertile
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• the majority of ovaries in 8 month old mice appeared hemorrhagic
|
|
|
• ovaries were histologically normal through 21 days of age
• defects became apparent after 3 months of age
|
|
|
• some mice developed Sertoli cell tubule-like structures, reminiscent of the ovarian tumors observed in mice inhibin-deficient mice, mice overexpressing follistatin and follicle stimulating hormone, mice lacking both estrogen receptors alpha and beta, and mice overexpressing anti-Mullerian hormone
|
|
|
• decreased numbers of antral follicles
|
ovary cyst
(
J:89081
)
|
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• observed in 2 mice
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• impaired ovulation in response to human chorionic gonadotropin (hCG) only in mature adult mice (6 months of age)
• however, superovulation was normal in 3-week-old mice
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• of 11 female experimental mice, 1 was completely infertile
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• of 11 female experimental mice, 10 showed reduced fertility, yielding reduced litter number and size
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• impaired fertilization only in mature adult mice (6 months of age)
• fertilization was normal in 3-week-old mice
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cardiovascular system
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• the majority of ovaries in 8 month old mice appeared hemorrhagic
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