Phenotypes associated with this allele

• Allele Symbol: Ahnak^tm1Vtm
• Allele Name: targeted mutation 1, Vincent T Marchesi
• Allele ID: MGI:3040870
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ahnak^tm1Vtm/Ahnak^tm1Vtm	involves: 129S1/Sv * C57BL/6	MGI:3041942

Genotype
MGI:3041942

hm1

• Allelic Composition: Ahnak^tm1Vtm/Ahnak^tm1Vtm
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T-helper 1 physiology ( J:131148 )

• mice do not mount an effective Th1 response to L. major footpad infection as measured by decreased production of IFN-gamma by CD4 T cells

abnormal T cell activation ( J:131148 )

• calcium influx of stimulated CD4 T cells is markedly reduced

decreased T cell proliferation ( J:131148 )

• CD 4 T cells stimulated with anti-CD3 antibody proliferate poorly with only 23% of cells undergoing cell division compared to 40% of wild-type controls

• exogenous administration of IL-2 rescues the proliferation defect

• addition of ionomycin also rescues the proliferation defect

decreased interferon-gamma secretion ( J:131148 )

• popliteal CD4 T cells from L. major infected mice secrete up to 10-fold less IFN-gamma than wild-type controls

decreased interleukin-2 secretion ( J:131148 )

• CD 4 T cells stimulated with anti-CD3 antibody for one or two days produce little IL-2

increased interleukin-4 secretion ( J:131148 )

• popliteal CD4 T cells from L. major infected mice secrete more IL-4 than wild-type controls

increased susceptibility to parasitic infection ( J:131148 )

• mice exhibit enhanced lesion development and a 100-fold increase in parasite burden after infection with L. major in the footpad

hematopoietic system

abnormal T-helper 1 physiology ( J:131148 )

• mice do not mount an effective Th1 response to L. major footpad infection as measured by decreased production of IFN-gamma by CD4 T cells

abnormal T cell activation ( J:131148 )

• calcium influx of stimulated CD4 T cells is markedly reduced

decreased T cell proliferation ( J:131148 )

• CD 4 T cells stimulated with anti-CD3 antibody proliferate poorly with only 23% of cells undergoing cell division compared to 40% of wild-type controls

• exogenous administration of IL-2 rescues the proliferation defect

• addition of ionomycin also rescues the proliferation defect

cellular

decreased T cell proliferation ( J:131148 )

• CD 4 T cells stimulated with anti-CD3 antibody proliferate poorly with only 23% of cells undergoing cell division compared to 40% of wild-type controls

• exogenous administration of IL-2 rescues the proliferation defect

• addition of ionomycin also rescues the proliferation defect