All Phenotypes Per2<tm1Jt> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Per2^tm1Jt
targeted mutation 1, Joseph S Takahashi
MGI:3040876

Summary

10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Per2^tm1Jt/Per2^tm1Jt	involves: 129S6/SvEvTac * C57BL/6J	MGI:3042019
cn2	Alb^{tm1(cre/ERT2)Mtz}/Alb⁺ Per2^tm1Jt/Per2⁺ Smg6^tm1.1Tac/Smg6^tm1.1Tac	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J	MGI:7571625
cx3	Cry2^tm1.1Yf/Cry2^tm1.1Yf Per2^tm1Jt/Per2^tm1Jt	B6J.Cg-Cry2^tm1.1Yf Per2^tm1Jt	MGI:5781227
cx4	Opn5^tm1.1Lan/Opn5^tm1.1Yau Per2^tm1Jt/Per2⁺	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6N * FVB/N	MGI:5897197
cx5	Opn5^tm1.1Lan/Opn5^tm1.1Lan Per2^tm1Jt/Per2⁺	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6N * FVB/N	MGI:5897196
cx6	Opn5^tm1.1Yau/Opn5^tm1.1Yau Per2^tm1Jt/Per2⁺	involves: 129S6/SvEvTac	MGI:5897200
cx7	Opn1sw^tm1.2Mnei/Opn1sw^tm1.2Mnei Per2^tm1Jt/Per2⁺	involves: 129S6/SvEvTac	MGI:5897206
cx8	Clock^m1Jt/Clock⁺ Per2^tm1Jt/Per2⁺ Usf1^soc/?	involves: 129S6/SvEvTac * BALB/cJ * C57BL/6J	MGI:5515433
cx9	Per2^tm1Jt/Per2⁺ Zfhx3^Sci/Zfhx3⁺	involves: 129S6/SvEvTac * BALB/cOlaHsd * C3H/HeH * C57BL/6J	MGI:5661032
cx10	Opn3^{tm2b(EUCOMM)Wtsi}/Opn3^{tm2b(EUCOMM)Wtsi} Per2^tm1Jt/Per2⁺	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6N * CBA	MGI:5897203

Allelic Composition	Per2^tm1Jt/Per2^tm1Jt
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Per2^tm1Jt mutation (2 available); any Per2 mutation (73 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:89256 )

• mice developed normally and showed no overt morphological abnormalities

Allelic Composition	Alb^{tm1(cre/ERT2)Mtz}/Alb⁺ Per2^tm1Jt/Per2⁺ Smg6^tm1.1Tac/Smg6^tm1.1Tac
Genetic Background	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alb^{tm1(cre/ERT2)Mtz} mutation (2 available); any Alb mutation (97 available)
Per2^tm1Jt mutation (2 available); any Per2 mutation (73 available)
Smg6^tm1.1Tac mutation (0 available); any Smg6 mutation (99 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal locomotor circadian rhythm ( J:342742 )

• when entrained on a light phase feeding regimen

prolonged circadian behavior period ( J:342742 )

• 3-hours longer period in liver explants

abnormal circadian behavior phase ( J:342742 )

• phase differences at the pre-mRNA level for many core clock genes in liver

abnormal circardian behavior entrainment ( J:342742 )

• when entrained on a light phase feeding regimen

Allelic Composition	Cry2^tm1.1Yf/Cry2^tm1.1Yf Per2^tm1Jt/Per2^tm1Jt
Genetic Background	B6J.Cg-Cry2^tm1.1Yf Per2^tm1Jt

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cry2^tm1.1Yf mutation (0 available); any Cry2 mutation (42 available)
Per2^tm1Jt mutation (2 available); any Per2 mutation (73 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

abnormal liver physiology ( J:224319 )

• bioluminescence rhythms recorded from cultured liver slices revealed a significantly lengthened circadian period of the liver peripheral clock relative to wild-type controls

Allelic Composition	Opn5^tm1.1Lan/Opn5^tm1.1Yau Per2^tm1Jt/Per2⁺
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6N * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opn5^tm1.1Lan mutation (0 available); any Opn5 mutation (19 available)
Opn5^tm1.1Yau mutation (0 available); any Opn5 mutation (19 available)
Per2^tm1Jt mutation (2 available); any Per2 mutation (73 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye physiology ( J:227078 )

• ex vivo corneal photoentrainment is abolished

Allelic Composition	Opn5^tm1.1Lan/Opn5^tm1.1Lan Per2^tm1Jt/Per2⁺
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6N * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opn5^tm1.1Lan mutation (0 available); any Opn5 mutation (19 available)
Per2^tm1Jt mutation (2 available); any Per2 mutation (73 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye physiology ( J:227078 )

• ex vivo corneal photoentrainment is abolished

Allelic Composition	Opn5^tm1.1Yau/Opn5^tm1.1Yau Per2^tm1Jt/Per2⁺
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opn5^tm1.1Yau mutation (0 available); any Opn5 mutation (19 available)
Per2^tm1Jt mutation (2 available); any Per2 mutation (73 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:227078 )

N	• mice exhibit normal retinal histology and normal optokinetic tracking reflex

abnormal eye physiology ( J:227078 )

• retinas fail to exhibit light/dark entrainment

Allelic Composition	Opn1sw^tm1.2Mnei/Opn1sw^tm1.2Mnei Per2^tm1Jt/Per2⁺
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opn1sw^tm1.2Mnei mutation (0 available); any Opn1sw mutation (22 available)
Per2^tm1Jt mutation (2 available); any Per2 mutation (73 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:227078 )

N	• retinas exhibit normal photoentrainment to white light, photosensitivity to violet light and corneal photoentrainment

Allelic Composition	Clock^m1Jt/Clock⁺ Per2^tm1Jt/Per2⁺ Usf1^soc/?
Genetic Background	involves: 129S6/SvEvTac * BALB/cJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clock^m1Jt mutation (3 available); any Clock mutation (104 available)
Per2^tm1Jt mutation (2 available); any Per2 mutation (73 available)
Usf1^soc mutation (0 available); any Usf1 mutation (81 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal circadian behavior period ( J:198519 )

• Background Sensitivity: shorter period compared to in mice on a background with more C57BL/6 contribution

Allelic Composition	Per2^tm1Jt/Per2⁺ Zfhx3^Sci/Zfhx3⁺
Genetic Background	involves: 129S6/SvEvTac * BALB/cOlaHsd * C3H/HeH * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Per2^tm1Jt mutation (2 available); any Per2 mutation (73 available)
Zfhx3^Sci mutation (2 available); any Zfhx3 mutation (130 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal hypothalamus physiology ( J:223990 )

• the suprachiasmatic nucleus has a shorter circadian period, the period distribution is broader, and relative amplitude error (RAE) is increased in individual neurons imaged across the suprachiasmatic nucleus circuit

Allelic Composition	Opn3^{tm2b(EUCOMM)Wtsi}/Opn3^{tm2b(EUCOMM)Wtsi} Per2^tm1Jt/Per2⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6N * CBA
Cell Lines	EPD0197_3_E01

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opn3^{tm2b(EUCOMM)Wtsi} mutation (0 available); any Opn3 mutation (25 available)
Per2^tm1Jt mutation (2 available); any Per2 mutation (73 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:227078 )

N	• retinas exhibit normal circadian photoentrainment and corneal photoentrainment

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