Phenotypes associated with this allele

• Allele Symbol: Zfp148^tm1Kii
• Allele Name: targeted mutation 1, Ken-ichi Isobe
• Allele ID: MGI:3040891
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Zfp148^tm1Kii/Zfp148^+	Not Specified	MGI:3040894

Genotype
MGI:3040894

ht1

• Allelic Composition: Zfp148^tm1Kii/Zfp148⁺
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:81445 )

♂ • chimeras with a high proportion of cells carrying one copy of the mutated allele have seminiferous tubules with only Sertoli cells and no gametes

small testis ( J:81445 )

♂ • chimeras with a high proportion of cells carrying one copy of the mutated allele have testes that are smaller compared to chimeras without the mutated allele

reproductive system

abnormal male germ cell apoptosis ( J:81445 )

♂ • haploinsufficiency in chimeras results in increased pro-spermatogonia cell death

abnormal seminiferous tubule morphology ( J:81445 )

♂ • chimeras with a high proportion of cells carrying one copy of the mutated allele have seminiferous tubules with only Sertoli cells and no gametes

small testis ( J:81445 )

♂ • chimeras with a high proportion of cells carrying one copy of the mutated allele have testes that are smaller compared to chimeras without the mutated allele

male infertility ( J:81445 )

♂ • chimeric males are sterile or do not have germ-line transmission

cellular

abnormal male germ cell apoptosis ( J:81445 )

♂ • haploinsufficiency in chimeras results in increased pro-spermatogonia cell death