Phenotypes associated with this allele

• Allele Symbol: Raf1^tm1Ulb
• Allele Name: targeted mutation 1, Catrin Pritchard
• Allele ID: MGI:3040971
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Raf1^tm1Ulb/Raf1^tm1Ulb	involves: 129P2/OlaHsd * C57BL/6	MGI:3046976
hm2	Raf1^tm1Ulb/Raf1^tm1Ulb	involves: 129P2/OlaHsd * MF1	MGI:3046977

Genotype
MGI:3046976

hm1

• Allelic Composition: Raf1^tm1Ulb/Raf1^tm1Ulb
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality ( J:89619 )

• mice on a mixed background involving 129P2/OlaHsd and MF1 had increased embryonic survival relative to those on a mixed background involving 129P2/OlaHsd and C57BL/6

cardiovascular system

abnormal vasculogenesis ( J:89619 )

absent vitelline blood vessels ( J:89619 )

hemorrhage ( J:89619 )

• observed in ~25% of mutants

cellular

abnormal apoptosis ( J:89619 )

• increased apoptosis throughout the mutant embryos

embryo

absent vitelline blood vessels ( J:89619 )

embryonic growth arrest ( J:89619 )

decreased embryo size ( J:89619 )

abnormal somite development ( J:89619 )

• fewer somites than wild-type

growth/size/body

decreased embryo size ( J:89619 )

decreased body weight ( J:89619 )

• mice on a mixed background involving 129P2/OlaHsd and MF1 were 50 to 60% lighter than those on a mixed background involving 129P2/OlaHsd and C57BL/6

hematopoietic system

anemia ( J:89619 )

liver/biliary system

liver hypoplasia ( J:89619 )

Genotype
MGI:3046977

hm2

• Allelic Composition: Raf1^tm1Ulb/Raf1^tm1Ulb
• Genetic Background: involves: 129P2/OlaHsd * MF1

mortality/aging

prenatal lethality ( J:89619 )

• mice on a mixed background involving 129P2/OlaHsd and MF1 had increased embryonic survival relative to those on a mixed background involving 129P2/OlaHsd and C57BL/6

embryo

embryonic growth arrest ( J:89619 )

decreased embryo size ( J:89619 )

abnormal somite development ( J:89619 )

abnormal placenta development ( J:89619 )

• small and disorganized

• the spongioblast layer was reduced in size, mesenchymal cells were undifferentiated, and there were fewer blood vessels than in wild-type

growth/size/body

decreased embryo size ( J:89619 )

decreased body weight ( J:89619 )

• mice on a mixed background involving 129P2/OlaHsd and MF1 were 50 to 60% lighter than those on a mixed background involving 129P2/OlaHsd and C57BL/6