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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Bmp4tm1Jfm
targeted mutation 1, James F Martin
MGI:3041440
Summary 22 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4tm1Jfm
Tg(Mef2c-cre)2Blk/0
involves: 129S4/SvJaeSor MGI:4941214
cn2
Bmp4tm1Jfm/Bmp4tm1Jfm
Tg(Mef2c-cre)2Blk/0
involves: 129S4/SvJaeSor MGI:4941218
cn3
Bmp4tm1Jfm/Bmp4tm1.1Jfm
Tg(Prrx1-cre)1Cjt/0
involves: 129S4/SvJaeSor MGI:3043045
cn4
Bmp4tm1Jfm/Bmp4tm1.1Jfm
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S4/SvJaeSor * 129S7/SvEvBrd MGI:3043044
cn5
Bmp4tm1Jfm/Bmp4tm1Jfm
Mirc1tm1.2Tyj/Mirc1tm1.2Tyj
Tg(Mef2c-cre)2Blk/0
involves: 129S4/SvJaeSor * C57BL/6 MGI:4941217
cn6
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4tm1Jfm
Bmp7tm1Jfm/Bmp7tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:5312868
cn7
Bmp2tm1Jfm/Bmp2+
Bmp4tm1Jfm/Bmp4+
Bmp7tm1Jfm/Bmp7tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:5312869
cn8
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4+
Bmp7tm1Jfm/Bmp7+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:5312870
cn9
Bmp2tm1Jfm/Bmp2+
Bmp4tm1Jfm/Bmp4tm1Jfm
Bmp7tm1Jfm/Bmp7+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:5312871
cn10
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4+
Bmp7tm1Jfm/Bmp7tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:5312873
cn11
Bmp2tm1Jfm/Bmp2+
Bmp4tm1Jfm/Bmp4tm1Jfm
Bmp7tm1Jfm/Bmp7tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:5312874
cn12
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4tm1Jfm
Bmp7tm1Jfm/Bmp7+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:5312875
cn13
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:5312864
cn14
Bmp4tm1Jfm/Bmp4tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:5312863
cn15
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:5312865
cn16
Bmp2tm1Jfm/Bmp2+
Bmp4tm1Jfm/Bmp4tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:5312866
cn17
Bmp4tm1Jfm/Bmp4tm1Jfm
Bmp7tm1Jfm/Bmp7tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:5312867
cn18
Bmp2tm1Cjt/Bmp2+
Bmp4tm1Jfm/Bmp4+
Tg(Prrx1-cre)1Cjt/0
involves: 129S4/SvJaeSor * C57BL/6 * SJL MGI:3700046
cn19
Bmp2tm1Cjt/Bmp2tm1Cjt
Bmp4tm1Jfm/Bmp4tm1Jfm
Tg(Prrx1-cre)1Cjt/0
involves: 129S4/SvJaeSor * C57BL/6 * SJL MGI:3700042
cn20
Bmp4tm1Jfm/Bmp4tm1Jfm
Tg(Prrx1-cre)1Cjt/0
involves: 129S4/SvJaeSor * C57BL/6 * SJL MGI:3768541
cn21
Bmp2tm1Cjt/Bmp2tm1Cjt
Bmp4tm1Jfm/Bmp4+
Tg(Prrx1-cre)1Cjt/0
involves: 129S4/SvJaeSor * C57BL/6 * SJL MGI:3700041
cn22
Bmp2tm1Cjt/Bmp2+
Bmp4tm1Jfm/Bmp4tm1Jfm
Tg(Prrx1-cre)1Cjt/0
involves: 129S4/SvJaeSor * C57BL/6 * SJL MGI:3700040


Genotype
MGI:4941214
cn1
Allelic
Composition
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4tm1Jfm
Tg(Mef2c-cre)2Blk/0
Genetic
Background
involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Jfm mutation (1 available); any Bmp2 mutation (27 available)
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
Tg(Mef2c-cre)2Blk mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
• dramatic reduction in the amount of sarcomeric myosin

homeostasis/metabolism




Genotype
MGI:4941218
cn2
Allelic
Composition
Bmp4tm1Jfm/Bmp4tm1Jfm
Tg(Mef2c-cre)2Blk/0
Genetic
Background
involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
Tg(Mef2c-cre)2Blk mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• defect in outflow tract remodeling at E12.5 due to a deficiency in proximal outflow tract mesenchyme
• at E14.5 and E18.5, a deficiency in the separation of the proximal outflow tract is seen
• at E14.5 and E18.5, the alignment of the aorta and pulmonary trunk is abnormal




Genotype
MGI:3043045
cn3
Allelic
Composition
Bmp4tm1Jfm/Bmp4tm1.1Jfm
Tg(Prrx1-cre)1Cjt/0
Genetic
Background
involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm1.1Jfm mutation (0 available); any Bmp4 mutation (23 available)
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• severely reduced outflow tract cushions, which developed into a shortened outflow tract




Genotype
MGI:3043044
cn4
Allelic
Composition
Bmp4tm1Jfm/Bmp4tm1.1Jfm
Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic
Background
involves: 129S4/SvJaeSor * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm1.1Jfm mutation (0 available); any Bmp4 mutation (23 available)
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
Nkx2-5tm1(cre)Rjs mutation (1 available); any Nkx2-5 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most mice died by E13.5, although an occasional fetus survived to E18.5, putatively due to variability in the expression of cre recombinase
• peripheral edema that was often associated with pericardial effusion indicated that lethality was secondary to heart failure

cardiovascular system
• severe defects in the architecture of the brancial arch artery due to impaired remodeling
• variable branching and abnormal regression and remodeling
• only one pulmonary artery originates from the ductus arteriosis and the fate of the second pulmonary artery is not clear
• majority exhibited a proximal aortopulmonary window, in which the proximal aspect of the outflow tract septum failed to form
• the left carotid artery branched either from the right brachiocephalic artery in the most severely affected embryos or directly from the aorta in more mildly affected embryos
• interruption (type B) of the aorta between the left carotid and the left subclavian arteries
• growth was delayed and the cushions were hypoplastic
• cell proliferation is reduced in the cushion mesenchyme, relative to wild-type
• observed in all examined fetuses
• putatively due to a defect in the conotruncal mesenchyme
• hypoplastic semilunar valves
• peripheral edema that was often associated with pericardial effusion

homeostasis/metabolism
• peripheral edema that was often associated with pericardial effusion
• peripheral edema that was often associated with pericardial effusion

craniofacial
• severe defects in the architecture of the brancial arch artery due to impaired remodeling
• variable branching and abnormal regression and remodeling

embryo
• severe defects in the architecture of the brancial arch artery due to impaired remodeling
• variable branching and abnormal regression and remodeling




Genotype
MGI:4941217
cn5
Allelic
Composition
Bmp4tm1Jfm/Bmp4tm1Jfm
Mirc1tm1.2Tyj/Mirc1tm1.2Tyj
Tg(Mef2c-cre)2Blk/0
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
Mirc1tm1.2Tyj mutation (1 available); any Mirc1 mutation (6 available)
Tg(Mef2c-cre)2Blk mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• proximal outflow tract mesenchyme deficiency is more severe than in mutant mice wild-type for Mir17-92
• failure of fusion between proximal mesenchyme and outflow tract septum
• at E14.5 and E18.5, a deficiency in the separation of the proximal outflow tract is seen
• deficiency is more severe than in mutant mice wild-type for Mir17-92




Genotype
MGI:5312868
cn6
Allelic
Composition
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4tm1Jfm
Bmp7tm1Jfm/Bmp7tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Jfm mutation (1 available); any Bmp2 mutation (27 available)
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
Bmp7tm1Jfm mutation (0 available); any Bmp7 mutation (37 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• drastic reduction in most cranial neural crest derived bones
• enlarged frontal fontanelle at E18.5
• phenotype is more severe than in conditional null mice wild-type for Bmp2
• pieces of the interparietal bone are absent
• mandibular defects at E18.5
• phenotype is more severe than in conditional null mice wild-type for Bmp2
• pieces of the nasal bone are absent

hearing/vestibular/ear

skeleton
• drastic reduction in most cranial neural crest derived bones
• enlarged frontal fontanelle at E18.5
• phenotype is more severe than in conditional null mice wild-type for Bmp2
• pieces of the interparietal bone are absent
• mandibular defects at E18.5
• phenotype is more severe than in conditional null mice wild-type for Bmp2
• pieces of the nasal bone are absent

digestive/alimentary system

growth/size/body
• pieces of the nasal bone are absent

respiratory system
• pieces of the nasal bone are absent




Genotype
MGI:5312869
cn7
Allelic
Composition
Bmp2tm1Jfm/Bmp2+
Bmp4tm1Jfm/Bmp4+
Bmp7tm1Jfm/Bmp7tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Jfm mutation (1 available); any Bmp2 mutation (27 available)
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
Bmp7tm1Jfm mutation (0 available); any Bmp7 mutation (37 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial

hearing/vestibular/ear

digestive/alimentary system

skeleton

growth/size/body




Genotype
MGI:5312870
cn8
Allelic
Composition
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4+
Bmp7tm1Jfm/Bmp7+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Jfm mutation (1 available); any Bmp2 mutation (27 available)
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
Bmp7tm1Jfm mutation (0 available); any Bmp7 mutation (37 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype



Genotype
MGI:5312871
cn9
Allelic
Composition
Bmp2tm1Jfm/Bmp2+
Bmp4tm1Jfm/Bmp4tm1Jfm
Bmp7tm1Jfm/Bmp7+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Jfm mutation (1 available); any Bmp2 mutation (27 available)
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
Bmp7tm1Jfm mutation (0 available); any Bmp7 mutation (37 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype



Genotype
MGI:5312873
cn10
Allelic
Composition
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4+
Bmp7tm1Jfm/Bmp7tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Jfm mutation (1 available); any Bmp2 mutation (27 available)
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
Bmp7tm1Jfm mutation (0 available); any Bmp7 mutation (37 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype



Genotype
MGI:5312874
cn11
Allelic
Composition
Bmp2tm1Jfm/Bmp2+
Bmp4tm1Jfm/Bmp4tm1Jfm
Bmp7tm1Jfm/Bmp7tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Jfm mutation (1 available); any Bmp2 mutation (27 available)
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
Bmp7tm1Jfm mutation (0 available); any Bmp7 mutation (37 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial

hearing/vestibular/ear

digestive/alimentary system

skeleton

growth/size/body

respiratory system




Genotype
MGI:5312875
cn12
Allelic
Composition
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4tm1Jfm
Bmp7tm1Jfm/Bmp7+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Jfm mutation (1 available); any Bmp2 mutation (27 available)
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
Bmp7tm1Jfm mutation (0 available); any Bmp7 mutation (37 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• pieces of the interparietal bone are absent
• pieces of the condyloid process are absent
• pieces of the nasal bone are absent

hearing/vestibular/ear

skeleton
• pieces of the interparietal bone are absent
• pieces of the condyloid process are absent
• pieces of the nasal bone are absent

digestive/alimentary system

growth/size/body
• pieces of the nasal bone are absent

respiratory system
• pieces of the nasal bone are absent




Genotype
MGI:5312864
cn13
Allelic
Composition
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Jfm mutation (1 available); any Bmp2 mutation (27 available)
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• drastic reduction in most cranial neural crest derived bones
• enlarged frontal fontanelle at E18.5
• phenotype is more severe than in conditional null mice wild-type for Bmp2
• pieces of the interparietal bone are absent
• pieces of the squamosal bone are absent
• mandibular defects at E18.5
• phenotype is more severe than in conditional null mice wild-type for Bmp2
• pieces of the condyloid process are absent
• pieces of the nasal bone are absent

hearing/vestibular/ear

skeleton
• drastic reduction in most cranial neural crest derived bones
• enlarged frontal fontanelle at E18.5
• phenotype is more severe than in conditional null mice wild-type for Bmp2
• pieces of the interparietal bone are absent
• pieces of the squamosal bone are absent
• mandibular defects at E18.5
• phenotype is more severe than in conditional null mice wild-type for Bmp2
• pieces of the condyloid process are absent
• pieces of the nasal bone are absent

digestive/alimentary system

growth/size/body
• pieces of the nasal bone are absent

respiratory system
• pieces of the nasal bone are absent




Genotype
MGI:5312863
cn14
Allelic
Composition
Bmp4tm1Jfm/Bmp4tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• expression analysis indicates a defect in the transition from pre-osteoblast to osteoblast
• enlarged frontal fontanelle at E18.5
• subtle mandibular defects at E18.5

cellular
• expression analysis indicates a defect in the transition from pre-osteoblast to osteoblast

craniofacial
• enlarged frontal fontanelle at E18.5
• subtle mandibular defects at E18.5




Genotype
MGI:5312865
cn15
Allelic
Composition
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Jfm mutation (1 available); any Bmp2 mutation (27 available)
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype



Genotype
MGI:5312866
cn16
Allelic
Composition
Bmp2tm1Jfm/Bmp2+
Bmp4tm1Jfm/Bmp4tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Jfm mutation (1 available); any Bmp2 mutation (27 available)
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial

skeleton




Genotype
MGI:5312867
cn17
Allelic
Composition
Bmp4tm1Jfm/Bmp4tm1Jfm
Bmp7tm1Jfm/Bmp7tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
Bmp7tm1Jfm mutation (0 available); any Bmp7 mutation (37 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• enlarged frontal fontanelle at E18.5
• subtle mandibular defects at E18.5

hearing/vestibular/ear

digestive/alimentary system

skeleton
• enlarged frontal fontanelle at E18.5
• subtle mandibular defects at E18.5

growth/size/body




Genotype
MGI:3700046
cn18
Allelic
Composition
Bmp2tm1Cjt/Bmp2+
Bmp4tm1Jfm/Bmp4+
Tg(Prrx1-cre)1Cjt/0
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Cjt mutation (0 available); any Bmp2 mutation (27 available)
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mutants show no defects in limb patterning and skeletogenesis




Genotype
MGI:3700042
cn19
Allelic
Composition
Bmp2tm1Cjt/Bmp2tm1Cjt
Bmp4tm1Jfm/Bmp4tm1Jfm
Tg(Prrx1-cre)1Cjt/0
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Cjt mutation (0 available); any Bmp2 mutation (27 available)
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Mice deficient singly or in various combinations of Bmp2, Bmp4 and Bmp7 display limb defects

embryo
• AER is expanded and maintained much later (>E15.5) than in wild-type
• at E11.5, limb buds are noticeably broader relative to wild-type

immune system
• has not yet started at birth

limbs/digits/tail
• interdigital apoptosis is reduced at E15.5
• AER is expanded and maintained much later (>E15.5) than in wild-type
• at E11.5, limb buds are noticeably broader relative to wild-type
• at E15.5 autopod adopts notched pallet form, with only distal tip of each digit separated
• autopod elements are reduced in size
• the two posterior-most digits are missing in the forelimbs
• in newborns, the digits of both forelimb and hindlimb show complete syndactyly
• in the limbs of E15.5 embryos, only the very distal tip of each digit is separated, with the autopod adopting the shape of a notched pallet
• mice have short and malformed stylopods
• one of the zeugopod elements is almost always missing, while the other is so deformed it is hard to accurately identify
• mice have short and malformed stylopods
• one of the zeugopod elements is almost always missing, while the other is so deformed it is hard to accurately identify

skeleton
• at 3 weeks, all mineralized cartilage in diaphyseal region has disappeared, leaving a void where bone formation should have occurred
• cavity formation is delayed
• loss of posterior digits in the forelimbs due to failure of chondrogenesis in this region as indicated by marker analysis
• joint articulations are defective such that the zeugopod and stylopod elements are fused
• 1-3 weeks after birth, no bone marrow cavity, trabecular bone, or cortical bone is present
• at 1-3 weeks after birth , bone formation is not observed in femur for example; skeletal elements in mutants remain similar to E17.5 structures seen in wild-type limbs
• in E17.5 limbs, delay in endochondral process is observed; bone morphology at birth resembles E17.5 in wild-type

cellular
• interdigital apoptosis is reduced at E15.5




Genotype
MGI:3768541
cn20
Allelic
Composition
Bmp4tm1Jfm/Bmp4tm1Jfm
Tg(Prrx1-cre)1Cjt/0
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Mice deficient singly or in various combinations of Bmp2, Bmp4 and Bmp7 display limb defects

limbs/digits/tail
• mice exhibit variable penetrance of preaxial and postaxial polydactyly, however exhibit normal digit patterns




Genotype
MGI:3700041
cn21
Allelic
Composition
Bmp2tm1Cjt/Bmp2tm1Cjt
Bmp4tm1Jfm/Bmp4+
Tg(Prrx1-cre)1Cjt/0
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Cjt mutation (0 available); any Bmp2 mutation (27 available)
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Mice deficient singly or in various combinations of Bmp2, Bmp4 and Bmp7 display limb defects

skeleton
• mice have more severe skeletal defects than Bmp2-heterozygous, Bmp4-homozygous mice, including significantly thinner skeletal elements
• animals do not have abnormal digit patterns




Genotype
MGI:3700040
cn22
Allelic
Composition
Bmp2tm1Cjt/Bmp2+
Bmp4tm1Jfm/Bmp4tm1Jfm
Tg(Prrx1-cre)1Cjt/0
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Cjt mutation (0 available); any Bmp2 mutation (27 available)
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Mice deficient singly or in various combinations of Bmp2, Bmp4 and Bmp7 display limb defects

limbs/digits/tail
• mice exhibit variable penetrance pre- and postaxial syndactyly





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory