About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Bmp4tm1Jfm
targeted mutation 1, James F Martin
MGI:3041440
Summary 22 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4tm1Jfm
Tg(Mef2c-cre)2Blk/0
involves: 129S4/SvJaeSor MGI:4941214
cn2
Bmp4tm1Jfm/Bmp4tm1Jfm
Tg(Mef2c-cre)2Blk/0
involves: 129S4/SvJaeSor MGI:4941218
cn3
Bmp4tm1Jfm/Bmp4tm1.1Jfm
Tg(Prrx1-cre)1Cjt/0
involves: 129S4/SvJaeSor MGI:3043045
cn4
Bmp4tm1Jfm/Bmp4tm1.1Jfm
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S4/SvJaeSor * 129S7/SvEvBrd MGI:3043044
cn5
Bmp4tm1Jfm/Bmp4tm1Jfm
Mirc1tm1.2Tyj/Mirc1tm1.2Tyj
Tg(Mef2c-cre)2Blk/0
involves: 129S4/SvJaeSor * C57BL/6 MGI:4941217
cn6
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4tm1Jfm
Bmp7tm1Jfm/Bmp7tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:5312868
cn7
Bmp2tm1Jfm/Bmp2+
Bmp4tm1Jfm/Bmp4+
Bmp7tm1Jfm/Bmp7tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:5312869
cn8
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4+
Bmp7tm1Jfm/Bmp7+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:5312870
cn9
Bmp2tm1Jfm/Bmp2+
Bmp4tm1Jfm/Bmp4tm1Jfm
Bmp7tm1Jfm/Bmp7+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:5312871
cn10
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4+
Bmp7tm1Jfm/Bmp7tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:5312873
cn11
Bmp2tm1Jfm/Bmp2+
Bmp4tm1Jfm/Bmp4tm1Jfm
Bmp7tm1Jfm/Bmp7tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:5312874
cn12
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4tm1Jfm
Bmp7tm1Jfm/Bmp7+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:5312875
cn13
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:5312864
cn14
Bmp4tm1Jfm/Bmp4tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:5312863
cn15
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:5312865
cn16
Bmp2tm1Jfm/Bmp2+
Bmp4tm1Jfm/Bmp4tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:5312866
cn17
Bmp4tm1Jfm/Bmp4tm1Jfm
Bmp7tm1Jfm/Bmp7tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:5312867
cn18
Bmp2tm1Cjt/Bmp2+
Bmp4tm1Jfm/Bmp4+
Tg(Prrx1-cre)1Cjt/0
involves: 129S4/SvJaeSor * C57BL/6 * SJL MGI:3700046
cn19
Bmp2tm1Cjt/Bmp2tm1Cjt
Bmp4tm1Jfm/Bmp4tm1Jfm
Tg(Prrx1-cre)1Cjt/0
involves: 129S4/SvJaeSor * C57BL/6 * SJL MGI:3700042
cn20
Bmp4tm1Jfm/Bmp4tm1Jfm
Tg(Prrx1-cre)1Cjt/0
involves: 129S4/SvJaeSor * C57BL/6 * SJL MGI:3768541
cn21
Bmp2tm1Cjt/Bmp2tm1Cjt
Bmp4tm1Jfm/Bmp4+
Tg(Prrx1-cre)1Cjt/0
involves: 129S4/SvJaeSor * C57BL/6 * SJL MGI:3700041
cn22
Bmp2tm1Cjt/Bmp2+
Bmp4tm1Jfm/Bmp4tm1Jfm
Tg(Prrx1-cre)1Cjt/0
involves: 129S4/SvJaeSor * C57BL/6 * SJL MGI:3700040


Genotype
MGI:4941214
cn1
Allelic
Composition
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4tm1Jfm
Tg(Mef2c-cre)2Blk/0
Genetic
Background
involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Jfm mutation (1 available); any Bmp2 mutation (27 available)
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
Tg(Mef2c-cre)2Blk mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
• dramatic reduction in the amount of sarcomeric myosin

homeostasis/metabolism




Genotype
MGI:4941218
cn2
Allelic
Composition
Bmp4tm1Jfm/Bmp4tm1Jfm
Tg(Mef2c-cre)2Blk/0
Genetic
Background
involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
Tg(Mef2c-cre)2Blk mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• defect in outflow tract remodeling at E12.5 due to a deficiency in proximal outflow tract mesenchyme
• at E14.5 and E18.5, a deficiency in the separation of the proximal outflow tract is seen
• at E14.5 and E18.5, the alignment of the aorta and pulmonary trunk is abnormal




Genotype
MGI:3043045
cn3
Allelic
Composition
Bmp4tm1Jfm/Bmp4tm1.1Jfm
Tg(Prrx1-cre)1Cjt/0
Genetic
Background
involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm1.1Jfm mutation (0 available); any Bmp4 mutation (23 available)
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• severely reduced outflow tract cushions, which developed into a shortened outflow tract




Genotype
MGI:3043044
cn4
Allelic
Composition
Bmp4tm1Jfm/Bmp4tm1.1Jfm
Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic
Background
involves: 129S4/SvJaeSor * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm1.1Jfm mutation (0 available); any Bmp4 mutation (23 available)
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
Nkx2-5tm1(cre)Rjs mutation (1 available); any Nkx2-5 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most mice died by E13.5, although an occasional fetus survived to E18.5, putatively due to variability in the expression of cre recombinase
• peripheral edema that was often associated with pericardial effusion indicated that lethality was secondary to heart failure

cardiovascular system
• severe defects in the architecture of the brancial arch artery due to impaired remodeling
• variable branching and abnormal regression and remodeling
• only one pulmonary artery originates from the ductus arteriosis and the fate of the second pulmonary artery is not clear
• majority exhibited a proximal aortopulmonary window, in which the proximal aspect of the outflow tract septum failed to form
• the left carotid artery branched either from the right brachiocephalic artery in the most severely affected embryos or directly from the aorta in more mildly affected embryos
• interruption (type B) of the aorta between the left carotid and the left subclavian arteries
• growth was delayed and the cushions were hypoplastic
• cell proliferation is reduced in the cushion mesenchyme, relative to wild-type
• observed in all examined fetuses
• putatively due to a defect in the conotruncal mesenchyme
• hypoplastic semilunar valves
• peripheral edema that was often associated with pericardial effusion

homeostasis/metabolism
• peripheral edema that was often associated with pericardial effusion
• peripheral edema that was often associated with pericardial effusion

craniofacial
• severe defects in the architecture of the brancial arch artery due to impaired remodeling
• variable branching and abnormal regression and remodeling

embryo
• severe defects in the architecture of the brancial arch artery due to impaired remodeling
• variable branching and abnormal regression and remodeling




Genotype
MGI:4941217
cn5
Allelic
Composition
Bmp4tm1Jfm/Bmp4tm1Jfm
Mirc1tm1.2Tyj/Mirc1tm1.2Tyj
Tg(Mef2c-cre)2Blk/0
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
Mirc1tm1.2Tyj mutation (1 available); any Mirc1 mutation (6 available)
Tg(Mef2c-cre)2Blk mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• proximal outflow tract mesenchyme deficiency is more severe than in mutant mice wild-type for Mir17-92
• failure of fusion between proximal mesenchyme and outflow tract septum
• at E14.5 and E18.5, a deficiency in the separation of the proximal outflow tract is seen
• deficiency is more severe than in mutant mice wild-type for Mir17-92




Genotype
MGI:5312868
cn6
Allelic
Composition
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4tm1Jfm
Bmp7tm1Jfm/Bmp7tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Jfm mutation (1 available); any Bmp2 mutation (27 available)
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
Bmp7tm1Jfm mutation (0 available); any Bmp7 mutation (37 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• drastic reduction in most cranial neural crest derived bones
• enlarged frontal fontanelle at E18.5
• phenotype is more severe than in conditional null mice wild-type for Bmp2
• pieces of the interparietal bone are absent
• mandibular defects at E18.5
• phenotype is more severe than in conditional null mice wild-type for Bmp2
• pieces of the nasal bone are absent

hearing/vestibular/ear

skeleton
• drastic reduction in most cranial neural crest derived bones
• enlarged frontal fontanelle at E18.5
• phenotype is more severe than in conditional null mice wild-type for Bmp2
• pieces of the interparietal bone are absent
• mandibular defects at E18.5
• phenotype is more severe than in conditional null mice wild-type for Bmp2
• pieces of the nasal bone are absent

digestive/alimentary system

growth/size/body
• pieces of the nasal bone are absent

respiratory system
• pieces of the nasal bone are absent




Genotype
MGI:5312869
cn7
Allelic
Composition
Bmp2tm1Jfm/Bmp2+
Bmp4tm1Jfm/Bmp4+
Bmp7tm1Jfm/Bmp7tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Jfm mutation (1 available); any Bmp2 mutation (27 available)
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
Bmp7tm1Jfm mutation (0 available); any Bmp7 mutation (37 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial

hearing/vestibular/ear

digestive/alimentary system

skeleton

growth/size/body




Genotype
MGI:5312870
cn8
Allelic
Composition
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4+
Bmp7tm1Jfm/Bmp7+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Jfm mutation (1 available); any Bmp2 mutation (27 available)
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
Bmp7tm1Jfm mutation (0 available); any Bmp7 mutation (37 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype



Genotype
MGI:5312871
cn9
Allelic
Composition
Bmp2tm1Jfm/Bmp2+
Bmp4tm1Jfm/Bmp4tm1Jfm
Bmp7tm1Jfm/Bmp7+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Jfm mutation (1 available); any Bmp2 mutation (27 available)
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
Bmp7tm1Jfm mutation (0 available); any Bmp7 mutation (37 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype



Genotype
MGI:5312873
cn10
Allelic
Composition
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4+
Bmp7tm1Jfm/Bmp7tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Jfm mutation (1 available); any Bmp2 mutation (27 available)
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
Bmp7tm1Jfm mutation (0 available); any Bmp7 mutation (37 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype



Genotype
MGI:5312874
cn11
Allelic
Composition
Bmp2tm1Jfm/Bmp2+
Bmp4tm1Jfm/Bmp4tm1Jfm
Bmp7tm1Jfm/Bmp7tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Jfm mutation (1 available); any Bmp2 mutation (27 available)
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
Bmp7tm1Jfm mutation (0 available); any Bmp7 mutation (37 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial

hearing/vestibular/ear

digestive/alimentary system

skeleton

growth/size/body

respiratory system




Genotype
MGI:5312875
cn12
Allelic
Composition
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4tm1Jfm
Bmp7tm1Jfm/Bmp7+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Jfm mutation (1 available); any Bmp2 mutation (27 available)
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
Bmp7tm1Jfm mutation (0 available); any Bmp7 mutation (37 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• pieces of the interparietal bone are absent
• pieces of the condyloid process are absent
• pieces of the nasal bone are absent

hearing/vestibular/ear

skeleton
• pieces of the interparietal bone are absent
• pieces of the condyloid process are absent
• pieces of the nasal bone are absent

digestive/alimentary system

growth/size/body
• pieces of the nasal bone are absent

respiratory system
• pieces of the nasal bone are absent




Genotype
MGI:5312864
cn13
Allelic
Composition
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Jfm mutation (1 available); any Bmp2 mutation (27 available)
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• drastic reduction in most cranial neural crest derived bones
• enlarged frontal fontanelle at E18.5
• phenotype is more severe than in conditional null mice wild-type for Bmp2
• pieces of the interparietal bone are absent
• pieces of the squamosal bone are absent
• mandibular defects at E18.5
• phenotype is more severe than in conditional null mice wild-type for Bmp2
• pieces of the condyloid process are absent
• pieces of the nasal bone are absent

hearing/vestibular/ear

skeleton
• drastic reduction in most cranial neural crest derived bones
• enlarged frontal fontanelle at E18.5
• phenotype is more severe than in conditional null mice wild-type for Bmp2
• pieces of the interparietal bone are absent
• pieces of the squamosal bone are absent
• mandibular defects at E18.5
• phenotype is more severe than in conditional null mice wild-type for Bmp2
• pieces of the condyloid process are absent
• pieces of the nasal bone are absent

digestive/alimentary system

growth/size/body
• pieces of the nasal bone are absent

respiratory system
• pieces of the nasal bone are absent




Genotype
MGI:5312863
cn14
Allelic
Composition
Bmp4tm1Jfm/Bmp4tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• expression analysis indicates a defect in the transition from pre-osteoblast to osteoblast
• enlarged frontal fontanelle at E18.5
• subtle mandibular defects at E18.5

cellular
• expression analysis indicates a defect in the transition from pre-osteoblast to osteoblast

craniofacial
• enlarged frontal fontanelle at E18.5
• subtle mandibular defects at E18.5




Genotype
MGI:5312865
cn15
Allelic
Composition
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Jfm mutation (1 available); any Bmp2 mutation (27 available)
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype



Genotype
MGI:5312866
cn16
Allelic
Composition
Bmp2tm1Jfm/Bmp2+
Bmp4tm1Jfm/Bmp4tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Jfm mutation (1 available); any Bmp2 mutation (27 available)
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial

skeleton




Genotype
MGI:5312867
cn17
Allelic
Composition
Bmp4tm1Jfm/Bmp4tm1Jfm
Bmp7tm1Jfm/Bmp7tm1Jfm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
Bmp7tm1Jfm mutation (0 available); any Bmp7 mutation (37 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• enlarged frontal fontanelle at E18.5
• subtle mandibular defects at E18.5

hearing/vestibular/ear

digestive/alimentary system

skeleton
• enlarged frontal fontanelle at E18.5
• subtle mandibular defects at E18.5

growth/size/body




Genotype
MGI:3700046
cn18
Allelic
Composition
Bmp2tm1Cjt/Bmp2+
Bmp4tm1Jfm/Bmp4+
Tg(Prrx1-cre)1Cjt/0
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Cjt mutation (0 available); any Bmp2 mutation (27 available)
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mutants show no defects in limb patterning and skeletogenesis




Genotype
MGI:3700042
cn19
Allelic
Composition
Bmp2tm1Cjt/Bmp2tm1Cjt
Bmp4tm1Jfm/Bmp4tm1Jfm
Tg(Prrx1-cre)1Cjt/0
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Cjt mutation (0 available); any Bmp2 mutation (27 available)
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Mice deficient singly or in various combinations of Bmp2, Bmp4 and Bmp7 display limb defects

embryo
• AER is expanded and maintained much later (>E15.5) than in wild-type
• at E11.5, limb buds are noticeably broader relative to wild-type

immune system
• has not yet started at birth

limbs/digits/tail
• interdigital apoptosis is reduced at E15.5
• AER is expanded and maintained much later (>E15.5) than in wild-type
• at E11.5, limb buds are noticeably broader relative to wild-type
• at E15.5 autopod adopts notched pallet form, with only distal tip of each digit separated
• autopod elements are reduced in size
• the two posterior-most digits are missing in the forelimbs
• in newborns, the digits of both forelimb and hindlimb show complete syndactyly
• in the limbs of E15.5 embryos, only the very distal tip of each digit is separated, with the autopod adopting the shape of a notched pallet
• mice have short and malformed stylopods
• one of the zeugopod elements is almost always missing, while the other is so deformed it is hard to accurately identify
• mice have short and malformed stylopods
• one of the zeugopod elements is almost always missing, while the other is so deformed it is hard to accurately identify

skeleton
• at 3 weeks, all mineralized cartilage in diaphyseal region has disappeared, leaving a void where bone formation should have occurred
• cavity formation is delayed
• loss of posterior digits in the forelimbs due to failure of chondrogenesis in this region as indicated by marker analysis
• joint articulations are defective such that the zeugopod and stylopod elements are fused
• 1-3 weeks after birth, no bone marrow cavity, trabecular bone, or cortical bone is present
• at 1-3 weeks after birth , bone formation is not observed in femur for example; skeletal elements in mutants remain similar to E17.5 structures seen in wild-type limbs
• in E17.5 limbs, delay in endochondral process is observed; bone morphology at birth resembles E17.5 in wild-type

cellular
• interdigital apoptosis is reduced at E15.5




Genotype
MGI:3768541
cn20
Allelic
Composition
Bmp4tm1Jfm/Bmp4tm1Jfm
Tg(Prrx1-cre)1Cjt/0
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Mice deficient singly or in various combinations of Bmp2, Bmp4 and Bmp7 display limb defects

limbs/digits/tail
• mice exhibit variable penetrance of preaxial and postaxial polydactyly, however exhibit normal digit patterns




Genotype
MGI:3700041
cn21
Allelic
Composition
Bmp2tm1Cjt/Bmp2tm1Cjt
Bmp4tm1Jfm/Bmp4+
Tg(Prrx1-cre)1Cjt/0
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Cjt mutation (0 available); any Bmp2 mutation (27 available)
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Mice deficient singly or in various combinations of Bmp2, Bmp4 and Bmp7 display limb defects

skeleton
• mice have more severe skeletal defects than Bmp2-heterozygous, Bmp4-homozygous mice, including significantly thinner skeletal elements
• animals do not have abnormal digit patterns




Genotype
MGI:3700040
cn22
Allelic
Composition
Bmp2tm1Cjt/Bmp2+
Bmp4tm1Jfm/Bmp4tm1Jfm
Tg(Prrx1-cre)1Cjt/0
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Cjt mutation (0 available); any Bmp2 mutation (27 available)
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Mice deficient singly or in various combinations of Bmp2, Bmp4 and Bmp7 display limb defects

limbs/digits/tail
• mice exhibit variable penetrance pre- and postaxial syndactyly





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory