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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Nr5a1-cre)5Asc
transgene insertion 5, Andreas Schedl
MGI:3041879
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Sox8tm1Weg/Sox8tm1Weg
Sox9tm2Crm/Sox9tm2Crm
Tg(Nr5a1-cre)5Asc/? 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA MGI:3719091
cn2
 		Sox8tm1Weg/Sox8+
Sox9tm2Crm/Sox9tm2Crm
Tg(Nr5a1-cre)5Asc/? 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA MGI:3719092
cn3
 		Sox9tm2Crm/Sox9tm2Crm
Tg(Nr5a1-cre)5Asc/? 		involves: 129S7/SvEvBrd * C57BL/6 * CBA MGI:3719089
cn4
 		Sox9tm2Crm/Sox9+
Tg(Nr5a1-cre)5Asc/? 		involves: 129S7/SvEvBrd * C57BL/6 * CBA MGI:3719090
cn5
 		Ctnnb1tm1Mmt/Ctnnb1+
Rspo1tm1Mcch/Rspo1tm1Mcch
Tg(Nr5a1-cre)5Asc/? 		involves: 129/Sv * C57BL/6 * CBA MGI:3795284


Genotype
MGI:3719091
cn1
Allelic
Composition		 Sox8tm1Weg/Sox8tm1Weg
Sox9tm2Crm/Sox9tm2Crm
Tg(Nr5a1-cre)5Asc/?
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox8tm1Weg mutation (0 available); any Sox8 mutation (28 available)
Sox9tm2Crm mutation (1 available); any Sox9 mutation (33 available)
Tg(Nr5a1-cre)5Asc mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
decreased Sertoli cell number ( J:89368 )
• at E18.5, Sertoli cells are absent
absent Leydig cells ( J:89368 )
• at E18.5, Leydig cells are absent
cryptorchism ( J:89368 )
• by E18.5 testes have not descended caudally

reproductive system
decreased Sertoli cell number ( J:89368 )
• at E18.5, Sertoli cells are absent
absent Leydig cells ( J:89368 )
• at E18.5, Leydig cells are absent
cryptorchism ( J:89368 )
• by E18.5 testes have not descended caudally
abnormal primary sex determination ( J:89368 )
• gonads develop very few or no sex chords
• XY males exhibit ovarian differentiation
sex reversal ( J:89368 )
• 1 in 3 male mice undergoes sex reversal




Genotype
MGI:3719092
cn2
Allelic
Composition		 Sox8tm1Weg/Sox8+
Sox9tm2Crm/Sox9tm2Crm
Tg(Nr5a1-cre)5Asc/?
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox8tm1Weg mutation (0 available); any Sox8 mutation (28 available)
Sox9tm2Crm mutation (1 available); any Sox9 mutation (33 available)
Tg(Nr5a1-cre)5Asc mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
decreased Sertoli cell number ( J:89368 )
• at E18.5, Sertoli cells are absent
absent Leydig cells ( J:89368 )
• at E18.5, Leydig cells are absent
cryptorchism ( J:89368 )
• by E18.5 testes have not descended caudally
abnormal primary sex determination ( J:89368 )
• gonads develop very few or no sex chords
• XY males exhibit ovarian differentiation
sex reversal ( J:89368 )
• 40% of mice undergo sex reversal

endocrine/exocrine glands
decreased Sertoli cell number ( J:89368 )
• at E18.5, Sertoli cells are absent
absent Leydig cells ( J:89368 )
• at E18.5, Leydig cells are absent
cryptorchism ( J:89368 )
• by E18.5 testes have not descended caudally




Genotype
MGI:3719089
cn3
Allelic
Composition		 Sox9tm2Crm/Sox9tm2Crm
Tg(Nr5a1-cre)5Asc/?
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox9tm2Crm mutation (1 available); any Sox9 mutation (33 available)
Tg(Nr5a1-cre)5Asc mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal male meiosis ( J:89368 )
• at E18.5, mice have a significant number of meiotic gonocytes (prophase) located in the seminiferous tubules next to quiescent gonocytes whereas gonocyte meiosis is inhibited in wild-type mice
abnormal seminiferous tubule morphology ( J:89368 )
• gonads have fewer seminiferous cords and their outline is irregular
abnormal testis development ( J:89368 )
• at E13.5, male testis development is abnormal in a proportion of mice
• however, testes descend normally

endocrine/exocrine glands
abnormal seminiferous tubule morphology ( J:89368 )
• gonads have fewer seminiferous cords and their outline is irregular
abnormal testis development ( J:89368 )
• at E13.5, male testis development is abnormal in a proportion of mice
• however, testes descend normally

cellular
abnormal male meiosis ( J:89368 )
• at E18.5, mice have a significant number of meiotic gonocytes (prophase) located in the seminiferous tubules next to quiescent gonocytes whereas gonocyte meiosis is inhibited in wild-type mice




Genotype
MGI:3719090
cn4
Allelic
Composition		 Sox9tm2Crm/Sox9+
Tg(Nr5a1-cre)5Asc/?
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox9tm2Crm mutation (1 available); any Sox9 mutation (33 available)
Tg(Nr5a1-cre)5Asc mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:89368 )
• a small proportion of mice die soon after birth

growth/size/body
disproportionate dwarf ( J:89368 )
• a small proportion of mice have campomelic dysplasia (a form of short-limbed dwarfism)




Genotype
MGI:3795284
cn5
Allelic
Composition		 Ctnnb1tm1Mmt/Ctnnb1+
Rspo1tm1Mcch/Rspo1tm1Mcch
Tg(Nr5a1-cre)5Asc/?
Genetic
Background		 involves: 129/Sv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (49 available)
Rspo1tm1Mcch mutation (0 available); any Rspo1 mutation (21 available)
Tg(Nr5a1-cre)5Asc mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, incomplete penetrance ( J:133933 )
• majority of embryos die during early embryonic development due to extensive Beta-catenin activation

reproductive system
reproductive system phenotype ( J:133933 )
N
• female mice that survive to birth have a normal reproductive system without the masculinazation of genitalia normally associated with Rspo1 null mice




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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory