All Phenotypes Sox9<tm2.1Crm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sox9^tm2.1Crm
targeted mutation 2.1, Benoit de Crombrugghe
MGI:3041881

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sox9^tm2.1Crm/Sox9^tm2.1Crm	involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * C57BL/6J	MGI:3719088
cx2	Sox8^tm1Weg/Sox8^tm1Weg Sox9^tm2.1Crm/Sox9⁺	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * C57BL/6J	MGI:3719087

Allelic Composition	Sox9^tm2.1Crm/Sox9^tm2.1Crm
Genetic Background	involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox9^tm2.1Crm mutation (0 available); any Sox9 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:89368 )

• mice die at E11.5 due to cardiac failure

reproductive system

abnormal primary sex determination ( J:89368 )

• no sex chords form in XY mice

cardiovascular system

congestive heart failure ( J:89368 )

• mice die at E11.5 due to cardiac failure

Allelic Composition	Sox8^tm1Weg/Sox8^tm1Weg Sox9^tm2.1Crm/Sox9⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox8^tm1Weg mutation (0 available); any Sox8 mutation (26 available)
Sox9^tm2.1Crm mutation (0 available); any Sox9 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal seminiferous tubule morphology ( J:89368 )

• at E15.5, male mice have fewer seminiferous tubules

abnormal primary sex determination ( J:89368 )

• 3 of 3 mice exhibit abnormal sex chord development and a clearly outlined coelomic vessel

sex reversal ( J:89368 )

• at E15.5, male mice have areas resembling an ovary

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:89368 )

• at E15.5, male mice have fewer seminiferous tubules

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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