Analysis Tools|
Allele Symbol Allele Name Allele ID |
Mapk3tm1Gela targeted mutation 1, Gary E Landreth MGI:3042006 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutant mice have a tendency to be more active in the open field than wild-type mice but are otherwise normal, healthy and fertile
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| N |
• mutant mice have normal long term potentiation response to theta burst stimulation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• nulls on the 129 background show increased Ag-induced production of Il17 and decreased Il5 production compared to wild-type 129 mice
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• in the MOG35-55 induced model of EAE, Mapk3-deficient mice and controls of either background show susceptibility to EAE; knockouts on the 129 background show increased susceptibility compared to 129 control mice
• inflammation is mildly increased in Erk1-deficient mice on the 129 background compared to 129 controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice are viable
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| N |
• mice develop normally
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• cerebral cortex morphology (cellular density, thickness, laminar organization) is not different from controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• more severe than in mice with normal Mapk3
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• more severe than in mice with normal Mapk3
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• more severe than in mice with normal Mapk3
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• more severe than in mice with normal Mapk3
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• in 3 of 3 mice at E16.5 and E17.5
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• in 3 of 3 mice at E16.5 and E17.5
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• single-lobed, fused and misplaced
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• singled-lobed and medially localized
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• more severe than in mice with normal Mapk3
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• single-lobed, fused and misplaced
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• single-lobed, fused and misplaced
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• more severe than in mice with normal Mapk3
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• more severe than in mice with normal Mapk3
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• more severe than in mice heterozygous for Mapk3tm1Gela
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• at E10.5
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• in 5 of 5 mice at E16.5 and E17.5
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• in 5 of 5 mice at E16.5 and E17.5
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• singled-lobed and medially localized
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• at E10.5
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• more severe than in mice heterozygous for Mapk3tm1Gela
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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