Phenotypes associated with this allele

• Allele Symbol: Ace^tm5Keb
• Allele Name: targeted mutation 5, Kenneth E Bernstein
• Allele ID: MGI:3042130
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ace^tm5Keb/Ace^tm5Keb	involves: 129S1/Sv * 129X1/SvJ	MGI:3042131
hm2	Ace^tm5Keb/Ace^tm5Keb	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4830269
ht3	Ace^tm1Keb/Ace^tm5Keb	involves: 129S1/Sv * 129X1/SvJ	MGI:3042132

Genotype
MGI:3042131

hm1

• Allelic Composition: Ace^tm5Keb/Ace^tm5Keb
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:89512 )

N • blood pressure and plasma renin and angiotensisn I concentrations are normal

N • homozygotes are not anemic and recover normally after induced red blood cell lysis

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:163902 )

N • the ratio of angiotensin I to II in the plasma is normal

decreased angiotensin I-converting enzyme activity ( J:89512 )

• N-terminal catalytic activity is absent in homozygotes and conversion of angiotensin I into angiotensin II is reduced compared to wild-type mice

renal/urinary system

renal/urinary system phenotype ( J:89512 )

N • kidney development and function are normal

Genotype
MGI:4830269

hm2

• Allelic Composition: Ace^tm5Keb/Ace^tm5Keb
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

mortality/aging

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:163454 )

• mice treated with a high dose of bleomycin

homeostasis/metabolism

increased angiotensin I-converting enzyme activity ( J:163454 )

• activity of the N-terminus (measured by N-acetyl-seryl-aspartyl-lysyl-proline hydrolysis) is increased compared to in wild-type mice

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:163454 )

• mice treated with a high dose of bleomycin

decreased susceptibility to injury ( J:163454 )

• bleomycin-treated mice exhibit reduced lung injury with reduced or absent alveolar cell hyperplasia, interstitial pneumonitis, focal fibrosis, elevation in hydroxyproline lung content, weight loss, and mortality (at high doses) compared with similarly treated wild-type mice

• however, inhibition of N-acetyl-seryl-aspartyl-lysyl-proline generation with S-17092 restores bleomycin-induced injury measured by lung fibrosis and hydroxyproline lung content

Genotype
MGI:3042132

ht3

• Allelic Composition: Ace^tm1Keb/Ace^tm5Keb
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

homeostasis/metabolism

increased circulating renin level ( J:89512 )

• plasma renin levels are elevated although less than in mice homozygous for Ace^tm1Keb

decreased angiotensin I-converting enzyme activity ( J:89512 )

• conversion of angiotensin I into angiotensin II is reduced compared to wild-type mice and mice homozygous for Ace^tm5Keb