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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pdctm1Vya
targeted mutation 1, Vadim Y Arshavsky
MGI:3042204
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pdctm1Vya/Pdctm1Vya involves: 129S6/SvEvTac * C57BL/6J MGI:3042206
cx2
 		Gngt1tm1Dgen/Gngt1tm1Dgen
Pdctm1Vya/Pdctm1Vya 		involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 MGI:3783809


Genotype
MGI:3042206
hm1
Allelic
Composition		 Pdctm1Vya/Pdctm1Vya
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdctm1Vya mutation (1 available); any Pdc mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal eye physiology ( J:89499 )
• light induced translocation of transducin (Gnat1) is significantly reduced
• retinal morphology and rod function are normal




Genotype
MGI:3783809
cx2
Allelic
Composition		 Gngt1tm1Dgen/Gngt1tm1Dgen
Pdctm1Vya/Pdctm1Vya
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gngt1tm1Dgen mutation (0 available); any Gngt1 mutation (14 available)
Pdctm1Vya mutation (1 available); any Pdc mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
retina photoreceptor degeneration ( J:133487 )
• degeneration proceeds at a rate similar to that in Gngt1 single homozygotes

vision/eye
retina photoreceptor degeneration ( J:133487 )
• degeneration proceeds at a rate similar to that in Gngt1 single homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory