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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pla2g5tm1Jarm
targeted mutation 1, Jonathan P Arm
MGI:3042209
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pla2g5tm1Jarm/Pla2g5tm1Jarm B6.129-Pla2g5tm1Jarm MGI:5517577
hm2
 		Pla2g5tm1Jarm/Pla2g5tm1Jarm C.129-Pla2g5tm1Jarm MGI:4358872
hm3
 		Pla2g5tm1Jarm/Pla2g5tm1Jarm involves: 129 * BALB/c MGI:4358871
hm4
 		Pla2g5tm1Jarm/Pla2g5tm1Jarm involves: 129 * C57BL/6 MGI:4358876
hm5
 		Pla2g5tm1Jarm/Pla2g5tm1Jarm involves: 129 * C57BL/6J MGI:3042212


Genotype
MGI:5517577
hm1
Allelic
Composition		 Pla2g5tm1Jarm/Pla2g5tm1Jarm
Genetic
Background		 B6.129-Pla2g5tm1Jarm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pla2g5tm1Jarm mutation (0 available); any Pla2g5 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:197334 )
N
• in a model of IgE antigen-dependent passive cutaneous anaphylaxis, mice exhibit normal edema
impaired macrophage phagocytosis ( J:110309 )
• after stimulation with zymosan, peritoneal macrophages exhibit decreased phagocytosis compared with similarly treated wild-type mice

hematopoietic system
impaired macrophage phagocytosis ( J:110309 )
• after stimulation with zymosan, peritoneal macrophages exhibit decreased phagocytosis compared with similarly treated wild-type mice

cellular
impaired macrophage phagocytosis ( J:110309 )
• after stimulation with zymosan, peritoneal macrophages exhibit decreased phagocytosis compared with similarly treated wild-type mice




Genotype
MGI:4358872
hm2
Allelic
Composition		 Pla2g5tm1Jarm/Pla2g5tm1Jarm
Genetic
Background		 C.129-Pla2g5tm1Jarm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pla2g5tm1Jarm mutation (0 available); any Pla2g5 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired macrophage phagocytosis ( J:110309 )
• after stimulation with zymosan, peritoneal macrophages exhibit decreased phagocytosis compared with similarly treated wild-type mice
• however, expression of group V sPLA2 restores phagocytosis

hematopoietic system
impaired macrophage phagocytosis ( J:110309 )
• after stimulation with zymosan, peritoneal macrophages exhibit decreased phagocytosis compared with similarly treated wild-type mice
• however, expression of group V sPLA2 restores phagocytosis

cellular
impaired macrophage phagocytosis ( J:110309 )
• after stimulation with zymosan, peritoneal macrophages exhibit decreased phagocytosis compared with similarly treated wild-type mice
• however, expression of group V sPLA2 restores phagocytosis




Genotype
MGI:4358871
hm3
Allelic
Composition		 Pla2g5tm1Jarm/Pla2g5tm1Jarm
Genetic
Background		 involves: 129 * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pla2g5tm1Jarm mutation (0 available); any Pla2g5 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired macrophage phagocytosis ( J:110309 )
• after stimulation with zymosan, peritoneal macrophages exhibit decreased phagocytosis compared with similarly treated wild-type mice

hematopoietic system
impaired macrophage phagocytosis ( J:110309 )
• after stimulation with zymosan, peritoneal macrophages exhibit decreased phagocytosis compared with similarly treated wild-type mice

cellular
impaired macrophage phagocytosis ( J:110309 )
• after stimulation with zymosan, peritoneal macrophages exhibit decreased phagocytosis compared with similarly treated wild-type mice




Genotype
MGI:4358876
hm4
Allelic
Composition		 Pla2g5tm1Jarm/Pla2g5tm1Jarm
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pla2g5tm1Jarm mutation (0 available); any Pla2g5 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system

hematopoietic system

cellular




Genotype
MGI:3042212
hm5
Allelic
Composition		 Pla2g5tm1Jarm/Pla2g5tm1Jarm
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pla2g5tm1Jarm mutation (0 available); any Pla2g5 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:89490 )
• arachadonic acid metabolite release from zymosan-stimulated peritoneal macrophages is reduced
decreased acute inflammation ( J:89490 )
• a reduction in plasma exudation is seen 30 minutes but not 60 minutes after intraperitoneal injection of a zymosan suspension in homozygotes compared to wild-type mice

hematopoietic system
abnormal macrophage physiology ( J:89490 )
• arachadonic acid metabolite release from zymosan-stimulated peritoneal macrophages is reduced




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory