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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pla2g5tm1Jarm
targeted mutation 1, Jonathan P Arm
MGI:3042209
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pla2g5tm1Jarm/Pla2g5tm1Jarm B6.129-Pla2g5tm1Jarm MGI:5517577
hm2
Pla2g5tm1Jarm/Pla2g5tm1Jarm C.129-Pla2g5tm1Jarm MGI:4358872
hm3
Pla2g5tm1Jarm/Pla2g5tm1Jarm involves: 129 * BALB/c MGI:4358871
hm4
Pla2g5tm1Jarm/Pla2g5tm1Jarm involves: 129 * C57BL/6 MGI:4358876
hm5
Pla2g5tm1Jarm/Pla2g5tm1Jarm involves: 129 * C57BL/6J MGI:3042212


Genotype
MGI:5517577
hm1
Allelic
Composition
Pla2g5tm1Jarm/Pla2g5tm1Jarm
Genetic
Background
B6.129-Pla2g5tm1Jarm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pla2g5tm1Jarm mutation (0 available); any Pla2g5 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• in a model of IgE antigen-dependent passive cutaneous anaphylaxis, mice exhibit normal edema
• after stimulation with zymosan, peritoneal macrophages exhibit decreased phagocytosis compared with similarly treated wild-type mice

hematopoietic system
• after stimulation with zymosan, peritoneal macrophages exhibit decreased phagocytosis compared with similarly treated wild-type mice

cellular
• after stimulation with zymosan, peritoneal macrophages exhibit decreased phagocytosis compared with similarly treated wild-type mice




Genotype
MGI:4358872
hm2
Allelic
Composition
Pla2g5tm1Jarm/Pla2g5tm1Jarm
Genetic
Background
C.129-Pla2g5tm1Jarm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pla2g5tm1Jarm mutation (0 available); any Pla2g5 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• after stimulation with zymosan, peritoneal macrophages exhibit decreased phagocytosis compared with similarly treated wild-type mice
• however, expression of group V sPLA2 restores phagocytosis

hematopoietic system
• after stimulation with zymosan, peritoneal macrophages exhibit decreased phagocytosis compared with similarly treated wild-type mice
• however, expression of group V sPLA2 restores phagocytosis

cellular
• after stimulation with zymosan, peritoneal macrophages exhibit decreased phagocytosis compared with similarly treated wild-type mice
• however, expression of group V sPLA2 restores phagocytosis




Genotype
MGI:4358871
hm3
Allelic
Composition
Pla2g5tm1Jarm/Pla2g5tm1Jarm
Genetic
Background
involves: 129 * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pla2g5tm1Jarm mutation (0 available); any Pla2g5 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• after stimulation with zymosan, peritoneal macrophages exhibit decreased phagocytosis compared with similarly treated wild-type mice

hematopoietic system
• after stimulation with zymosan, peritoneal macrophages exhibit decreased phagocytosis compared with similarly treated wild-type mice

cellular
• after stimulation with zymosan, peritoneal macrophages exhibit decreased phagocytosis compared with similarly treated wild-type mice




Genotype
MGI:4358876
hm4
Allelic
Composition
Pla2g5tm1Jarm/Pla2g5tm1Jarm
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pla2g5tm1Jarm mutation (0 available); any Pla2g5 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system

hematopoietic system

cellular




Genotype
MGI:3042212
hm5
Allelic
Composition
Pla2g5tm1Jarm/Pla2g5tm1Jarm
Genetic
Background
involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pla2g5tm1Jarm mutation (0 available); any Pla2g5 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• arachadonic acid metabolite release from zymosan-stimulated peritoneal macrophages is reduced
• a reduction in plasma exudation is seen 30 minutes but not 60 minutes after intraperitoneal injection of a zymosan suspension in homozygotes compared to wild-type mice

hematopoietic system
• arachadonic acid metabolite release from zymosan-stimulated peritoneal macrophages is reduced





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last database update
11/05/2024
MGI 6.24
The Jackson Laboratory