Phenotypes associated with this allele

• Allele Symbol: Hand1^tm1Cse
• Allele Name: targeted mutation 1, Peter Cserjesi
• Allele ID: MGI:3042297
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hand1^tm1Cse/Hand1^tm1Cse	either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)	MGI:3042299
hm2	Hand1^tm1Cse/Hand1^tm1Cse	involves: 129S1/Sv	MGI:3042298

Genotype
MGI:3042299

hm1

• Allelic Composition: Hand1^tm1Cse/Hand1^tm1Cse
• Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:89474 )

• on a mixed 129S1/Sv and C57BL/6 or Swiss Webster background embryos are reabsorbed starting after E7.75 with a large number surviving up to E9.5

embryo

abnormal extraembryonic endoderm formation ( J:89474 )

• on E9.5 the endoderm of the yolk sac is folded and gaps are seen between the endodermal and mesodermal layers of the yolk sac in homozygous mutants

abnormal vitelline vascular remodeling ( J:89474 )

• mature blood vessels are absent from homozygous yolk sacs on E8.5 - E9.5, however formation of the immature vascular plexus and hematopoiesis are normal

• on E8.5 - E9.5 smooth muscle cell recruitment to the vasculature is impaired in yolk sacs from homozygous mutants

Genotype
MGI:3042298

hm2

• Allelic Composition: Hand1^tm1Cse/Hand1^tm1Cse
• Genetic Background: involves: 129S1/Sv

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:89474 )

• on an inbred 129S1/Sv background embryos are reabsorbed at E7.5