Phenotypes associated with this allele

• Allele Symbol: Bmp10^tm1Shou
• Allele Name: targeted mutation 1, Weinian Shou
• Allele ID: MGI:3042354
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bmp10^tm1Shou/Bmp10^tm1Shou	either: 129S/SvEv or (involves: 129S/SvEv * C57BL/6J)	MGI:3042363
hm2	Bmp10^tm1Shou/Bmp10^tm1Shou	involves: 129S/SvEv	MGI:5708083

Genotype
MGI:3042363

hm1

• Allelic Composition: Bmp10^tm1Shou/Bmp10^tm1Shou
• Genetic Background: either: 129S/SvEv or (involves: 129S/SvEv * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:89476 )

• homozygotes die between E9.5 and E10.5

cardiovascular system

absent conotruncal ridges ( J:89476 )

• at E9.0 - 9.5 development of the endocardial cushions in the outflow tract is stopped at the acellular stage

absent atrioventricular cushions ( J:89476 )

• at E9.0 - 9.5 development of the endocardial cushions in atrio-ventricular canal is stopped at the acellular stage

ventricular hypoplasia ( J:89476 )

• at E9.0 - 9.5 the ventricular walls are hypoplastic probably as a result of a defect in myocyte proliferation

trabecula carnea hypoplasia ( J:89476 )

• at E9.0 - 9.5 primitive ventricular trabeculae are formed but fail to grow

decreased heart rate ( J:89476 )

• at E9.0 - 9.5 homozygous mutants hearts contract at a significantly slower rate compared to wild-type mice

muscle

trabecula carnea hypoplasia ( J:89476 )

• at E9.0 - 9.5 primitive ventricular trabeculae are formed but fail to grow

Genotype
MGI:5708083

hm2

• Allelic Composition: Bmp10^tm1Shou/Bmp10^tm1Shou
• Genetic Background: involves: 129S/SvEv

Absent vitelline vessels in the yolk sac, stalled vascular development at the primary capillary plexus stage, and arteriovenous malformation in Bmp10^tm1Shou/Bmp10^tm1Shou embryos

embryo

absent vitelline blood vessels ( J:222016 )

• at E10.5, vitelline vessels are absent

embryonic growth arrest ( J:222016 )

• homozygotes show severe developmental arrest by E10.5

decreased embryo size ( J:222016 )

• at E10.5, homozygotes are significantly smaller than wild-type embryos

abnormal vitelline vascular remodeling ( J:222016 )

• at E10.5, vascular development is stalled at the primary capillary plexus stage

cardiovascular system

abnormal vascular development ( J:222016 )

• although apparently normal at E8.5, homozygotes display defects in vascular development by E9.5

dilated dorsal aorta ( J:222016 )

• at E9.5

abnormal cardinal vein morphology ( J:222016 )

• at E9.5, cardinal veins are dilated

absent vitelline blood vessels ( J:222016 )

• at E10.5, vitelline vessels are absent

arteriovenous malformation ( J:222016 )

• at E9.5, the dorsal aorta and cardinal veins have fused to form a single continuous channel, unlike in wild-type controls

enlarged pericardium ( J:222016 )

• at E10.5

growth/size/body

decreased embryo size ( J:222016 )

• at E10.5, homozygotes are significantly smaller than wild-type embryos